MENTAL domain

{{Pfam_box

| Symbol = MENTAL

| Name = MENTAL domain

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| Pfam= PF10457

| InterPro= IPR019498

| SMART=

| Prosite = PS51439

| SCOP =

| TCDB =

| OPM family=

| OPM protein=

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}}

The MENTAL or MLN64 NH₂-terminal domain is a membrane-spanning domain that is conserved in two late endosomal proteins in vertebrates, MLN64 and MENTHO.{{cite journal |vauthors=Alpy F, Wendling C, Rio MC, Tomasetto C |title= MENTHO, a MLN64 Homologue Devoid of the START Domain. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 50780–7 |year= 2002 |pmid= 12393907 |doi= 10.1074/jbc.M208290200 |doi-access= free }} The domain is 170 amino acids long.

Current data indicates that this domain allows for dimerization between MLN64 and MENTHO molecules and with themselves.{{cite journal |vauthors=Alpy F, Latchumanan VK, Kedinger V, Janoshazi A, Thiele C, Wendling C, Rio MC, Tomasetto C |title= Functional characterization of the MENTAL domain. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 17945–52 |year= 2005 |pmid= 15718238 |doi= 10.1074/jbc.M500723200 |doi-access= free }} The domain may also direct cholesterol transport.