MEPE

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox protein family

| Symbol = Osteoregulin

| Name = Osteoregulin

| image =

| width =

| caption =

| Pfam = PF07175

| Pfam_clan =

| InterPro = IPR009837

| SMART =

| PROSITE =

| MEROPS =

| SCOP =

| TCDB =

| OPM family =

| OPM protein =

| CAZy =

| CDD =

}}

Matrix extracellular phosphoglycoprotein (Osteoblast/osteocyte factor 45) is a protein that in humans is encoded by the MEPE gene.{{cite journal |vauthors=Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL | title = MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia | journal = Genomics | volume = 67 | issue = 1 | pages = 54–68 |date=1 July 2000 | pmid = 10945470 | doi = 10.1006/geno.2000.6235 }}{{cite web | title = Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56955}} A conserved RGD motif is found in this protein, and this is potentially involved in integrin recognition.{{cite journal |vauthors=Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA | title = Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes | journal = J. Biol. Chem. | volume = 275 | issue = 46 | pages = 36172–80 |date=November 2000 | pmid = 10967096 | doi = 10.1074/jbc.M003622200 | doi-access = free }}

References

{{cite journal | author=Quarles LD |title=FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=285 |issue= 1 |pages= E1–9 |year= 2003 |pmid= 12791601 |doi= 10.1152/ajpendo.00016.2003 }}
{{cite journal |vauthors=Ogbureke KU, Fisher LW |title=Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). |journal=Kidney Int. |volume=68 |issue= 1 |pages= 155–66 |year= 2005 |pmid= 15954904 |doi= 10.1111/j.1523-1755.2005.00389.x |doi-access= free }}
{{cite journal |vauthors=Ogbureke KU, Fisher LW |title=Expression of SIBLINGs and their partner MMPs in salivary glands. |journal=J. Dent. Res. |volume=83 |issue= 9 |pages= 664–70 |year= 2004 |pmid= 15329369 |doi=10.1177/154405910408300902 |s2cid=17978869 }}
{{cite journal |vauthors=Jain A, Fedarko NS, Collins MT, etal |title=Serum levels of matrix extracellular phosphoglycoprotein (MEPE) in normal humans correlate with serum phosphorus, parathyroid hormone and bone mineral density. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 8 |pages= 4158–61 |year= 2004 |pmid= 15292364 |doi= 10.1210/jc.2003-032031 |doi-access= free }}
{{cite journal |vauthors=Nampei A, Hashimoto J, Hayashida K, etal |title=Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. |journal=J. Bone Miner. Metab. |volume=22 |issue= 3 |pages= 176–84 |year= 2005 |pmid= 15108058 |doi= 10.1007/s00774-003-0468-9 |s2cid=13194013 }}
{{cite journal |vauthors=MacDougall M, Simmons D, Gu TT, Dong J |title=MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. |journal=Connect. Tissue Res. |volume=43 |issue= 2–3 |pages= 320–30 |year= 2003 |pmid= 12489176 |doi=10.1080/713713461 }}
{{cite journal |vauthors=Argiro L, Desbarats M, Glorieux FH, Ecarot B |title=Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. |journal=Genomics |volume=74 |issue= 3 |pages= 342–51 |year= 2001 |pmid= 11414762 |doi= 10.1006/geno.2001.6553 }}

Category:Extracellular matrix proteins

MEPE

References

Further reading