MERTK

This gene is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

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• {{cite journal | vauthors = Iwase T, Tanaka M, Suzuki M, Naito Y, Sugimura H, Kino I | title = Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer | journal = Biochemical and Biophysical Research Communications | volume = 194 | issue = 2 | pages = 698–705 | date = July 1993 | pmid = 7688222 | doi = 10.1006/bbrc.1993.1878 | hdl = 10271/1029 | s2cid = 45988423 | hdl-access = free }}
• {{cite journal | vauthors = Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ | title = Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl | journal = The Journal of Biological Chemistry | volume = 271 | issue = 16 | pages = 9785–9 | date = April 1996 | pmid = 8621659 | doi = 10.1074/jbc.271.16.9785 | doi-access = free }}
• {{cite journal | vauthors = Ling L, Templeton D, Kung HJ | title = Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 31 | pages = 18355–62 | date = August 1996 | pmid = 8702477 | doi = 10.1074/jbc.271.31.18355 | doi-access = free }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Nagata K, Ohashi K, Nakano T, Arita H, Zong C, Hanafusa H, Mizuno K | title = Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 30022–7 | date = November 1996 | pmid = 8939948 | doi = 10.1074/jbc.271.47.30022 | doi-access = free }}
• {{cite journal | vauthors = Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H | title = Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1171–81 | date = February 1999 | pmid = 9891051 | pmc = 116046 | doi = 10.1128/mcb.19.2.1171}}
• {{cite journal | vauthors = Gal A, Li Y, Thompson DA, Weir J, Orth U, Jacobson SG, Apfelstedt-Sylla E, Vollrath D | title = Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa | journal = Nature Genetics | volume = 26 | issue = 3 | pages = 270–1 | date = November 2000 | pmid = 11062461 | doi = 10.1038/81555 | s2cid = 2812292 }}
• {{cite journal | vauthors = Thompson DA, McHenry CL, Li Y, Richards JE, Othman MI, Schwinger E, Vollrath D, Jacobson SG, Gal A | title = Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively | journal = American Journal of Human Genetics | volume = 70 | issue = 1 | pages = 224–9 | date = January 2002 | pmid = 11727200 | pmc = 384890 | doi = 10.1086/338455 }}
• {{cite journal | vauthors = Yin JL, Hambly BD, Bao SS, Painter D, Bishop GA, Eris JM | title = Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts | journal = Transplant International | volume = 16 | issue = 9 | pages = 681–8 | date = September 2003 | pmid = 12768229 | doi = 10.1007/s00147-003-0593-3 | s2cid = 13419387 }}
• {{cite journal | vauthors = McHenry CL, Liu Y, Feng W, Nair AR, Feathers KL, Ding X, Gal A, Vollrath D, Sieving PA, Thompson DA | title = MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells | journal = Investigative Ophthalmology & Visual Science | volume = 45 | issue = 5 | pages = 1456–63 | date = May 2004 | pmid = 15111602 | doi = 10.1167/iovs.03-0909 | doi-access = }}
• {{cite journal | vauthors = Chen C, Li Q, Darrow AL, Wang Y, Derian CK, Yang J, de Garavilla L, Andrade-Gordon P, Damiano BP | title = Mer receptor tyrosine kinase signaling participates in platelet function | journal = Arteriosclerosis, Thrombosis, and Vascular Biology | volume = 24 | issue = 6 | pages = 1118–23 | date = June 2004 | pmid = 15130911 | doi = 10.1161/01.ATV.0000130662.30537.08 | doi-access = free }}
• {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
• {{cite journal | vauthors = Li Y, Mahajan NP, Webster-Cyriaque J, Bhende P, Hong GK, Earp HS, Kenney S | title = The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1 | journal = Journal of Virology | volume = 78 | issue = 21 | pages = 11778–85 | date = November 2004 | pmid = 15479819 | pmc = 523243 | doi = 10.1128/JVI.78.21.11778-11785.2004 }}
• {{cite journal | vauthors = Gould WR, Baxi SM, Schroeder R, Peng YW, Leadley RJ, Peterson JT, Perrin LA | title = Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses | journal = Journal of Thrombosis and Haemostasis | volume = 3 | issue = 4 | pages = 733–41 | date = April 2005 | pmid = 15733062 | doi = 10.1111/j.1538-7836.2005.01186.x | s2cid = 20373626 | doi-access = }}
• {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
• {{cite journal | vauthors = Graham DK, Salzberg DB, Kurtzberg J, Sather S, Matsushima GK, Keating AK, Liang X, Lovell MA, Williams SA, Dawson TL, Schell MJ, Anwar AA, Snodgrass HR, Earp HS | title = Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia | journal = Clinical Cancer Research | volume = 12 | issue = 9 | pages = 2662–9 | date = May 2006 | pmid = 16675557 | doi = 10.1158/1078-0432.CCR-05-2208 | doi-access = free }}
• {{cite journal | vauthors = Tada A, Wada Y, Sato H, Itabashi T, Kawamura M, Tamai M, Nishida K | title = Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa | journal = Molecular Vision | volume = 12 | pages = 441–4 | date = May 2006 | pmid = 16710167 }}

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• [https://www.ncbi.nlm.nih.gov/books/NBK1417/ GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview]
• {{PDBe-KB2|Q12866|Tyrosine-protein kinase Mer}}

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{{Tyrosine kinases}}

{{Enzymes}}

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Category:Tyrosine kinase receptors

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