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MFN1

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.{{cite journal |vauthors=Adams MD, Kerlavage AR, Fields C, Venter JC | title = 3,400 new expressed sequence tags identify diversity of transcripts in human brain | journal = Nat Genet | volume = 4 | issue = 3 | pages = 256–67 |date=Sep 1993 | pmid = 8358434 | doi = 10.1038/ng0793-256 | s2cid = 20528590 }}{{cite journal |vauthors=Santel A, Fuller MT | title = Control of mitochondrial morphology by a human mitofusin | journal = J Cell Sci | volume = 114 | issue = Pt 5 | pages = 867–74 |date=Feb 2001 | doi = 10.1242/jcs.114.5.867 | pmid = 11181170 | doi-access = free }}

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.{{cite web | title = Entrez Gene: MFN1 mitofusin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55669}}

References

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Further reading

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  • {{cite journal |vauthors=Pawlikowska P, Orzechowski A |title=[Role of transmembrane GTPases in mitochondrial morphology and activity] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 53–9 |year= 2007 |pmid= 17718388 }}
  • {{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
  • {{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
  • {{cite journal |vauthors=Hales KG, Fuller MT |title=Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase |journal=Cell |volume=90 |issue= 1 |pages= 121–9 |year= 1997 |pmid= 9230308 |doi=10.1016/S0092-8674(00)80319-0 |s2cid=15162087 |doi-access=free }}
  • {{cite journal |vauthors=Chung JG, Yeh KT, Wu SL, etal |title=Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display |journal=Cancer Res. |volume=61 |issue= 24 |pages= 8873–9 |year= 2002 |pmid= 11751411 }}
  • {{cite journal |vauthors=Rojo M, Legros F, Chateau D, Lombès A |title=Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo |journal=J. Cell Sci. |volume=115 |issue= Pt 8 |pages= 1663–74 |year= 2003 |doi=10.1242/jcs.115.8.1663 |pmid= 11950885 }}
  • {{cite journal |vauthors=Legros F, Lombès A, Frachon P, Rojo M |title=Mitochondrial Fusion in Human Cells Is Efficient, Requires the Inner Membrane Potential, and Is Mediated by Mitofusins |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4343–54 |year= 2003 |pmid= 12475957 |doi= 10.1091/mbc.E02-06-0330 | pmc=138638 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Santel A, Frank S, Gaume B, etal |title=Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells |journal=J. Cell Sci. |volume=116 |issue= Pt 13 |pages= 2763–74 |year= 2004 |pmid= 12759376 |doi= 10.1242/jcs.00479 |doi-access= |s2cid=6661619 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L |title=OPA1 requires mitofusin 1 to promote mitochondrial fusion |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 45 |pages= 15927–32 |year= 2004 |pmid= 15509649 |doi= 10.1073/pnas.0407043101 | pmc=528769 |bibcode=2004PNAS..10115927C |doi-access=free }}
  • {{cite journal |vauthors=Cartoni R, Léger B, Hock MB, etal |title=Mitofusins 1/2 and ERRα expression are increased in human skeletal muscle after physical exercise |journal=J. Physiol. |volume=567 |issue= Pt 1 |pages= 349–58 |year= 2005 |pmid= 15961417 |doi= 10.1113/jphysiol.2005.092031 | pmc=1474174 }}

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