MFSD1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox gene}}

Major facilitator superfamily domain containing 1 (MFSD1, SMAP) is a protein belonging to the MFS Pfam clan.{{cite journal | vauthors = Perland E, Fredriksson R | title = Classification Systems of Secondary Active Transporters | journal = Trends in Pharmacological Sciences | volume = 38 | issue = 3 | pages = 305–315 | date = March 2017 | pmid = 27939446 | doi = 10.1016/j.tips.2016.11.008 }} It is an Atypical solute carrier.{{cite journal | vauthors = Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R | title = The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake | journal = Journal of Molecular Neuroscience | volume = 61 | issue = 2 | pages = 199–214 | date = February 2017 | pmid = 27981419 | doi = 10.1007/s12031-016-0867-8 | pmc = 5321710 }}

It belongs to the major facilitator superfamily MFS Pfam Clan. MFSD1 has been identified in neuronal plasma membranes and lysosomes.{{cite journal | vauthors = Chapel A, Kieffer-Jaquinod S, Sagné C, Verdon Q, Ivaldi C, Mellal M, Thirion J, Jadot M, Bruley C, Garin J, Gasnier B, Journet A | title = An extended proteome map of the lysosomal membrane reveals novel potential transporters | journal = Molecular & Cellular Proteomics | volume = 12 | issue = 6 | pages = 1572–88 | date = June 2013 | pmid = 23436907 | pmc = 3675815 | doi = 10.1074/mcp.M112.021980 | doi-access = free }}{{cite journal | vauthors = Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A | title = Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways | journal = Human Molecular Genetics | volume = 20 | issue = 19 | pages = 3852–66 | date = October 2011 | pmid = 21752829 | doi = 10.1093/hmg/ddr306 | doi-access = free }}

MFSD1 belongs to AMTF6.{{cite journal | vauthors = Perland E, Bagchi S, Klaesson A, Fredriksson R | title = Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression | language = en | journal = Open Biology | volume = 7 | issue = 9 | pages = 170142 | date = September 2017 | pmid = 28878041 | doi = 10.1098/rsob.170142 | pmc = 5627054 }}