MGST2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Microsomal glutathione S-transferase 2 is an enzyme that in humans is encoded by the MGST2 gene.{{cite journal |vauthors=Jakobsson PJ, Mancini JA, Ford-Hutchinson AW | title = Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase | journal = J Biol Chem | volume = 271 | issue = 36 | pages = 22203–10 |date=Oct 1996 | pmid = 8703034 | doi =10.1074/jbc.271.36.22203 | doi-access =free }}{{cite web | title = Entrez Gene: MGST2 microsomal glutathione S-transferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4258}}
The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4.
References
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Further reading
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- {{cite journal |vauthors=Jakobsson PJ, Morgenstern R, Mancini J, etal |title=Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. |journal=Am. J. Respir. Crit. Care Med. |volume=161 |issue= 2 Pt 2 |pages= S20–4 |year= 2000 |pmid= 10673221 |doi= 10.1164/ajrccm.161.supplement_1.ltta-5}}
- {{cite journal |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |doi-access=free }}
- {{cite journal |vauthors=Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW |title=Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22934–9 |year= 1997 |pmid= 9278457 |doi=10.1074/jbc.272.36.22934 |doi-access=free }}
- {{cite journal |vauthors=Jakobsson PJ, Scoggan KA, Yergey J, etal |title=Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. |journal=Journal of Lipid Mediators and Cell Signalling |volume=17 |issue= 1 |pages= 15–9 |year= 1998 |pmid= 9302651 |doi=10.1016/S0929-7855(97)00013-8 }}
- {{cite journal |vauthors=Sjöström M, Jakobsson PJ, Heimburger M, etal |title=Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. |journal=Eur. J. Biochem. |volume=268 |issue= 9 |pages= 2578–86 |year= 2001 |pmid= 11322876 |doi=10.1046/j.1432-1327.2001.02142.x |doi-access=free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Yang S, Yan KL, Zhang XJ, etal |title=Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. |journal=Arch. Dermatol. Res. |volume=298 |issue= 3 |pages= 107–12 |year= 2006 |pmid= 16773312 |doi= 10.1007/s00403-006-0670-4 |s2cid=20923145 }}
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