MIR195

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

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• {{cite journal |vauthors=Flavin RJ, Smyth PC, Laios A, O'Toole SA, Barrett C, Finn SP, Russell S, Ring M, Denning KM, Li J, Aherne ST, Sammarae DA, Aziz NA, Alhadi A, Sheppard BL, Lao K, Sheils OM, O'Leary JJ |title=Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma |journal=Mod. Pathol. |volume=22 |issue=2 |pages=197–205 |date=February 2009 |pmid=18677302 |doi=10.1038/modpathol.2008.135 |doi-access=free }}
• {{cite journal |vauthors=Liu L, Chen L, Xu Y, Li R, Du X |title=microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells |journal=Biochem. Biophys. Res. Commun. |volume=400 |issue=2 |pages=236–40 |date=September 2010 |pmid=20727858 |doi=10.1016/j.bbrc.2010.08.046 }}
• {{cite journal |vauthors=Gonsalves C, Kalra VK |title=Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195 |journal=J. Immunol. |volume=185 |issue=10 |pages=6253–64 |date=November 2010 |pmid=20952681 |doi=10.4049/jimmunol.1000660 |doi-access=free }}
• {{cite journal |vauthors=Li D, Zhao Y, Liu C, Chen X, Qi Y, Jiang Y, Zou C, Zhang X, Liu S, Wang X, Zhao D, Sun Q, Zeng Z, Dress A, Lin MC, Kung HF, Rui H, Liu LZ, Mao F, Jiang BH, Lai L |title=Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer |journal=Clin. Cancer Res. |volume=17 |issue=7 |pages=1722–30 |date=April 2011 |pmid=21350001 |doi=10.1158/1078-0432.CCR-10-1800 |doi-access=free |url=https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S1_from_Analysis_of_MiR-195_and_MiR-497_Expression_Regulation_and_Role_in_Breast_Cancer/22442933/1/files/39893828.pdf }}
• {{cite journal |vauthors=Wang X, Wang J, Ma H, Zhang J, Zhou X |title=Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer |journal=Med. Oncol. |volume=29 |issue=2 |pages=919–27 |date=June 2012 |pmid=21390519 |doi=10.1007/s12032-011-9880-5 |s2cid=19566991 }}
• {{cite journal |vauthors=Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N |title=Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation |journal=J. Cell. Physiol. |volume=226 |issue=10 |pages=2535–42 |date=October 2011 |pmid=21792910 |doi=10.1002/jcp.22598 |s2cid=42464226 }}
• {{cite journal |vauthors=Yang X, Yin J, Yu J, Xiang Q, Liu Y, Tang S, Liao D, Zhu B, Zu X, Tang H, Lei X |title=miRNA-195 sensitizes human hepatocellular carcinoma cells to 5-FU by targeting BCL-w |journal=Oncol. Rep. |volume=27 |issue=1 |pages=250–7 |date=January 2012 |pmid=21947305 |doi=10.3892/or.2011.1472 |doi-access=free }}
• {{cite journal |vauthors=Brenner B, Hoshen MB, Purim O, David MB, Ashkenazi K, Marshak G, Kundel Y, Brenner R, Morgenstern S, Halpern M, Rosenfeld N, Chajut A, Niv Y, Kushnir M |title=MicroRNAs as a potential prognostic factor in gastric cancer |journal=World J. Gastroenterol. |volume=17 |issue=35 |pages=3976–85 |date=September 2011 |pmid=22046085 |pmc=3199555 |doi=10.3748/wjg.v17.i35.3976 |doi-access=free }}
• {{cite journal |vauthors=Zhang QQ, Xu H, Huang MB, Ma LM, Huang QJ, Yao Q, Zhou H, Qu LH |title=MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion |journal=Neuro-Oncology |volume=14 |issue=3 |pages=278–87 |date=March 2012 |pmid=22217655 |pmc=3280801 |doi=10.1093/neuonc/nor216 }}

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