MIR503

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

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• {{cite journal |vauthors=Jiang Q, Feng MG, Mo YY |title=Systematic validation of predicted microRNAs for cyclin D1 |journal=BMC Cancer |volume=9 |pages=194 |year=2009 |pmid=19538740 |pmc=2728105 |doi=10.1186/1471-2407-9-194 |doi-access=free }}
• {{cite journal |vauthors=Sarkar S, Dey BK, Dutta A |title=MiR-322/424 and -503 are induced during muscle differentiation and promote cell cycle quiescence and differentiation by down-regulation of Cdc25A |journal=Mol. Biol. Cell |volume=21 |issue=13 |pages=2138–49 |year=2010 |pmid=20462953 |pmc=2893979 |doi=10.1091/mbc.E10-01-0062 }}
• {{cite journal |vauthors=Caporali A, Meloni M, Völlenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C |title=Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia |journal=Circulation |volume=123 |issue=3 |pages=282–91 |year=2011 |pmid=21220732 |doi=10.1161/CIRCULATIONAHA.110.952325 |doi-access=free }}
• {{cite journal |vauthors=Zhou J, Wang W |title=Analysis of microRNA expression profiling identifies microRNA-503 regulates metastatic function in hepatocellular cancer cell |journal=J Surg Oncol |volume=104 |issue=3 |pages=278–83 |year=2011 |pmid=21495032 |doi=10.1002/jso.21941 |s2cid=23582191 }}
• {{cite journal |vauthors=Cheng G, Sun S, Wang Z, Jin S |title=Investigation of the interaction between the MIR-503 and CD40 genes in irradiated U937 cells |journal=Radiat Oncol |volume=7 |pages=38 |year=2012 |pmid=22429276 |pmc=3325872 |doi=10.1186/1748-717X-7-38 |doi-access=free }}
• {{cite journal |vauthors=Roy P, Bhattacharya G, Lahiri A, Dasgupta UB, Banerjee D, Chandra S, Das M |title=hsa-miR-503 is downregulated in β thalassemia major |journal=Acta Haematol. |volume=128 |issue=3 |pages=187–9 |year=2012 |pmid=22890417 |doi=10.1159/000339492 |s2cid=5328558 }}
• {{cite journal |vauthors=Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, McLean DL, Park H, Comhair SA, Greif DM, Erzurum SC, Chun HJ |title=An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension |journal=Nat. Med. |volume=19 |issue=1 |pages=74–82 |year=2013 |pmid=23263626 |pmc=3540168 |doi=10.1038/nm.3040 }}
• {{cite journal |vauthors=Zhou B, Ma R, Si W, Li S, Xu Y, Tu X, Wang Q |title=MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth |journal=Cancer Lett. |volume=333 |issue=2 |pages=159–69 |year=2013 |pmid=23352645 |doi=10.1016/j.canlet.2013.01.028 }}
• {{cite journal |vauthors=Zhou R, Gong AY, Chen D, Miller RE, Eischeid AN, Chen XM |title=Histone deacetylases and NF-kB signaling coordinate expression of CX3CL1 in epithelial cells in response to microbial challenge by suppressing miR-424 and miR-503 |journal=PLOS ONE |volume=8 |issue=5 |pages=e65153 |year=2013 |pmid=23724129 |pmc=3665534 |doi=10.1371/journal.pone.0065153 |bibcode=2013PLoSO...865153Z |doi-access=free }}

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