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MIS12

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{about|the protein|the geological period|Marine Isotope Stage}}

{{Infobox_gene}}

Protein MIS12 homolog is a protein that in humans is encoded by the MIS12 gene.{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res | volume = 11 | issue = 3 | pages = 422–35 |date=Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}{{cite journal |vauthors=Goshima G, Kiyomitsu T, Yoda K, Yanagida M | title = Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway | journal = J Cell Biol | volume = 160 | issue = 1 | pages = 25–39 |date=Jan 2003 | pmid = 12515822 | pmc = 2172742 | doi = 10.1083/jcb.200210005 }}{{cite web | title = Entrez Gene: MIS12 MIS12, MIND kinetochore complex component, homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79003| accessdate = }}

Interactions

MIS12 has been shown to interact with NSL1,{{cite journal |last=Obuse |first=Chikashi |author2=Iwasaki Osamu |author3=Kiyomitsu Tomomi |author4=Goshima Gohta |author5=Toyoda Yusuke |author6=Yanagida Mitsuhiro |date=Nov 2004 |title=A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 |journal=Nat. Cell Biol. |volume=6 |issue=11 |pages=1135–41 |location = England| issn = 1465-7392| pmid = 15502821 |doi = 10.1038/ncb1187 |s2cid=39408000 }} ZWINT,{{cite journal |last=Cheeseman |first=Iain M |author2=Niessen Sherry |author3=Anderson Scott |author4=Hyndman Francie |author5=Yates John R |author6=Oegema Karen |author7=Desai Arshad |date=Sep 2004 |title=A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension |journal=Genes Dev. |volume=18 |issue=18 |pages=2255–68 |location = United States| issn = 0890-9369| pmid = 15371340 |doi = 10.1101/gad.1234104 |pmc=517519 }} CASC5, Polyamine-modulated factor 1, NDC80, DSN1 and CBX5.

References

{{Reflist}}

Further reading

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  • {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Cheeseman IM, Niessen S, Anderson S, etal |title=A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension |journal=Genes Dev. |volume=18 |issue= 18 |pages= 2255–68 |year= 2004 |pmid= 15371340 |doi= 10.1101/gad.1234104 | pmc=517519 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
  • {{cite journal |vauthors=Obuse C, Iwasaki O, Kiyomitsu T, etal |title=A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 |journal=Nat. Cell Biol. |volume=6 |issue= 11 |pages= 1135–41 |year= 2004 |pmid= 15502821 |doi= 10.1038/ncb1187 |s2cid=39408000 }}
  • {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
  • {{cite journal |vauthors=Kline SL, Cheeseman IM, Hori T, etal |title=The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation |journal=J. Cell Biol. |volume=173 |issue= 1 |pages= 9–17 |year= 2006 |pmid= 16585270 |doi= 10.1083/jcb.200509158 | pmc=2063780 }}

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{{Gene-17-stub}}