MMP10

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.{{cite web | title = Entrez Gene: MMP10 matrix metallopeptidase 10 (stromelysin 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4319}}

MMP10 has been linked to cancer stem cell vitality and metastasis.{{cite journal | vauthors = Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP | title = Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential | journal = PLOS ONE | volume = 7 | issue = 4 | pages = e35040 | year = 2012 | pmid = 22545096 | pmc = 3335833 | doi = 10.1371/journal.pone.0035040 | bibcode = 2012PLoSO...735040J | doi-access = free }}

MMP10 is a potential prognostic biomarker for oral cancer.{{cite journal | vauthors = Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, Arora P, Bal M, Nair S, Dutt A | title = Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases | journal = Oral Oncology | volume = 73 | pages = 56–64 | year = 2017 | pmid = 28939077 | pmc = 5628952 | doi = 10.1016/j.oraloncology.2017.08.003 }}{{Unreliable medical source|date=October 2017|sure=y}}

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• The MEROPS online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M10.006 M10.006]
• {{PDBe-KB2|P09238|Stromelysin-2}}

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{{Metalloendopeptidases}}

{{Enzymes}}

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Category:Matrix metalloproteinases

Category:EC 3.4.24

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