MOAP1
{{cs1 config|name-list-style=vanc}}
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.{{cite journal |vauthors=Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC | title = MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains | journal = J Biol Chem | volume = 276 | issue = 4 | pages = 2802–7 |date=May 2001 | pmid = 11060313 | doi = 10.1074/jbc.M008955200 | doi-access = free}}{{cite web | title = Entrez Gene: MOAP1 modulator of apoptosis 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64112}}
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |doi-access=free |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
- {{cite journal |vauthors=Baksh S, Tommasi S, Fenton S, etal |title=The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. |journal=Mol. Cell |volume=18 |issue= 6 |pages= 637–50 |year= 2005 |pmid= 15949439 |doi= 10.1016/j.molcel.2005.05.010 |doi-access= free }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Vos MD, Dallol A, Eckfeld K, etal |title=The RASSF1A tumor suppressor activates Bax via MOAP-1. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4557–63 |year= 2006 |pmid= 16344548 |doi= 10.1074/jbc.M512128200 |doi-access= free }}
- {{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
- {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |doi-access= free }}
- {{cite journal |vauthors=Fu NY, Sukumaran SK, Yu VC |title=Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 24 |pages= 10051–6 |year= 2007 |pmid= 17535899 |doi= 10.1073/pnas.0700007104 | pmc=1877986 |bibcode=2007PNAS..10410051F |doi-access=free }}
{{refend}}
{{gene-14-stub}}