MPO

• Myeloperoxidase, a peroxidase enzyme most abundantly present in neutrophil granulocytes
• .mpo (Multi Picture Object file extension), a 3D computer graphics image file format
• Medial preoptic area, a portion of the preoptic area of the hypothalamus
• Multi-fiber Push-On, a type of optical fiber connector
• Multiset path ordering, a well-ordering in term rewriting (computer science)
• Matrix Product Operator, a type of tensor network central to the Density Matrix Renormalisation Group numerical technique

• Mercury Planetary Orbiter, one component of the BepiColombo mission to Mercury
• Minor Planet Circulars Orbit Supplement, an astronomical publication from the Minor Planet Center
• Minor Planet Observer, an astronomical computer program partially based on the work of Mikko Kaasalainen

• Macedonian Patriotic Organization, a United States and Canadian organization supporting Macedonians
• Metropolitan planning organization, a type of transportation policy-making organization in the United States
• Malaysian Philharmonic Orchestra, a Malaysian orchestra based in Kuala Lumpur
• Managerial and Professional Officers, former British trade union
• Management and Planning Organization of Iran, a now-dissolved organization previously responsible for Iran's budget

• Metal Gear Solid: Portable Ops, a 2006 video game released for the PlayStation Portable
• Military Post Office, a key part of a military mail system
• Pocono Mountains Municipal Airport (IATA code), Pennsylvania, US
• Most Productive Overs method, in cricket
• Metropolitan planning organization, a federally mandated and funded transportation policy-making organization in the US
• Master of Prosthetics and Orthotics

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