MPP1
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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55 kDa erythrocyte membrane protein is a protein that in humans is encoded by the MPP1 gene.{{cite journal |vauthors=Ruff P, Speicher DW, Husain-Chishti A | title = Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 15 | pages = 6595–9 |date=Sep 1991 | pmid = 1713685 | pmc = 52133 | doi =10.1073/pnas.88.15.6595 | bibcode = 1991PNAS...88.6595R | doi-access = free }}{{cite web | title = Entrez Gene: MPP1 membrane protein, palmitoylated 1, 55kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4354| accessdate = }}
Palmitoylated membrane protein 1 is the prototype of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 1 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.
References
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Further reading
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- {{cite journal |vauthors=Metzenberg AB, Gitschier J |title=The gene encoding the palmitoylated erythrocyte membrane protein, p55, originates at the CpG island 3' to the factor VIII gene |journal=Hum. Mol. Genet. |volume=1 |issue= 2 |pages= 97–101 |year= 1993 |pmid= 1301163 |doi=10.1093/hmg/1.2.97 }}
- {{cite journal |vauthors=Bryant PJ, Woods DF |title=A major palmitoylated membrane protein of human erythrocytes shows homology to yeast guanylate kinase and to the product of a Drosophila tumor suppressor gene |journal=Cell |volume=68 |issue= 4 |pages= 621–2 |year= 1992 |pmid= 1310897 |doi=10.1016/0092-8674(92)90136-Z |s2cid=46607652 }}
- {{cite journal |author3-link=Daniel Branton |vauthors=Marfatia SM, Leu RA, Branton D, Chishti AH |title=Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 715–9 |year= 1995 |pmid= 7822301 |doi=10.1074/jbc.270.2.715 |doi-access=free }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Kim AC, Metzenberg AB, Sahr KE, etal |title=Complete genomic organization of the human erythroid p55 gene (MPP1), a membrane-associated guanylate kinase homologue |journal=Genomics |volume=31 |issue= 2 |pages= 223–9 |year= 1997 |pmid= 8824805 |doi= 10.1006/geno.1996.0035 }}
- {{cite journal |vauthors=Marfatia SM, Morais-Cabral JH, Kim AC, etal |title=The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24191–7 |year= 1997 |pmid= 9305870 |doi=10.1074/jbc.272.39.24191 |doi-access=free }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |hdl= 11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access= free }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Kusunoki H, Kohno T |title=Solution structure of human erythroid p55 PDZ domain |journal=Proteins |volume=64 |issue= 3 |pages= 804–7 |year= 2006 |pmid= 16741958 |doi= 10.1002/prot.21028 |doi-access= |s2cid=37573998 }}
- {{cite journal |vauthors=Gosens I, van Wijk E, Kersten FF, etal |title=MPP1 links the Usher protein network and the Crumbs protein complex in the retina |journal=Hum. Mol. Genet. |volume=16 |issue= 16 |pages= 1993–2003 |year= 2007 |pmid= 17584769 |doi= 10.1093/hmg/ddm147 |doi-access= free }}
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