MRPS24
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene.{{cite journal |vauthors=Xu L, He GP, Li A, Ro HS | title = Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs | journal = Nucleic Acids Res | volume = 22 | issue = 4 | pages = 646–55 |date=Apr 1994 | pmid = 8127713 | pmc = 307856 | doi =10.1093/nar/22.4.646 }}{{cite journal |vauthors=Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL | title = The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present | journal = J Biol Chem | volume = 276 | issue = 22 | pages = 19363–74 |date=May 2001 | pmid = 11279123 | doi = 10.1074/jbc.M100727200 | doi-access = free }}{{cite web | title = Entrez Gene: MRPS24 mitochondrial ribosomal protein S24| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64951}}
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11.
References
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Further reading
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- {{cite journal |vauthors=Mao M, Fu G, Wu JS, etal |title=Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 8175–80 |year= 1998 |pmid= 9653160 |doi=10.1073/pnas.95.14.8175 | pmc=20949 |bibcode=1998PNAS...95.8175M |doi-access=free }}
- {{cite journal |vauthors=Koc EC, Burkhart W, Blackburn K, etal |title=A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32585–91 |year= 2000 |pmid= 10938081 |doi= 10.1074/jbc.M003596200 |doi-access= free |url= https://cdr.lib.unc.edu/downloads/9019sb205 }}
- {{cite journal |vauthors=Suzuki T, Terasaki M, Takemoto-Hori C, etal |title=Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 33181–95 |year= 2001 |pmid= 11402041 |doi= 10.1074/jbc.M103236200 |doi-access= free }}
- {{cite journal |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1–2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 |bibcode=2003Sci...300..767S }}
- {{cite journal |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
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External links
- {{PDBe-KB2|Q96EL2|28S ribosomal protein S24, mitochondrial}}
{{GeneticTranslation}}
{{Ribosome subunits}}
{{gene-7-stub}}
{{protein-stub}}