MRPS5

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.

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• {{cite journal | vauthors = Zhang Z, Gerstein M | title = Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome | journal = Genomics | volume = 81 | issue = 5 | pages = 468–80 | date = May 2003 | pmid = 12706105 | doi = 10.1016/S0888-7543(03)00004-1 }}
• {{cite journal | vauthors = Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T | title = The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders | journal = Genomics | volume = 77 | issue = 1–2 | pages = 65–70 | date = Sep 2001 | pmid = 11543634 | doi = 10.1006/geno.2001.6622 }}
• {{cite journal | vauthors = Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K | title = Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33181–95 | date = Aug 2001 | pmid = 11402041 | doi = 10.1074/jbc.M103236200 | doi-access = free }}
• {{cite journal | vauthors = Koc EC, Burkhart W, Blackburn K, Koc H, Moseley A, Spremulli LL | title = Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach | journal = Protein Science | volume = 10 | issue = 3 | pages = 471–81 | date = Mar 2001 | pmid = 11344316 | pmc = 2374141 | doi = 10.1110/ps.35301 }}
• {{cite journal | vauthors = Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL | title = The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 19363–74 | date = Jun 2001 | pmid = 11279123 | doi = 10.1074/jbc.M100727200 | doi-access = free | citeseerx = 10.1.1.501.8919 }}

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• {{PDBe-KB2|P82675|28S ribosomal protein S5, mitochondrial}}

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{{Ribosome subunits}}

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Category:Ribosomal proteins