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MS4A3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.{{cite journal |vauthors=Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B | title = Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 21 | pages = 10178–82 |date=Nov 1994 | pmid = 7524084 | pmc = 44981 | doi =10.1073/pnas.91.21.10178 | bibcode =1994PNAS...9110178A | doi-access = free }}{{cite web | title = Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=932| accessdate = }}

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.

Interactions

MS4A3 has been shown to interact with CDKN3.{{cite journal |last=Donato |first=José L |author2=Ko Jon |author3=Kutok Jeffery L |author4=Cheng Tao |author5=Shirakawa Taro |author6=Mao Xiao-Quan |author7=Beach David |author8=Scadden David T |author9=Sayegh Mohamed H |author10=Adra Chaker N |date=Jan 2002 |title=Human HTm4 is a hematopoietic cell cycle regulator |journal=J. Clin. Invest. |volume=109 |issue=1 |pages=51–8 |location = United States| issn = 0021-9738| pmid = 11781350 |doi = 10.1172/JCI14025 |pmc=150822 }}

References

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Further reading

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  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Chinami M, Yano Y, Yang X, etal |title=Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17235–42 |year= 2005 |pmid= 15671017 |doi= 10.1074/jbc.M413437200 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Donato JL, Ko J, Kutok JL, etal |title=Human HTm4 is a hematopoietic cell cycle regulator. |journal=J. Clin. Invest. |volume=109 |issue= 1 |pages= 51–8 |year= 2002 |pmid= 11781350 |doi= 10.1172/JCI14025 | pmc=150822 }}
  • {{cite journal |vauthors=Liang Y, Buckley TR, Tu L, etal |title=Structural organization of the human MS4A gene cluster on Chromosome 11q12. |journal=Immunogenetics |volume=53 |issue= 5 |pages= 357–68 |year= 2001 |pmid= 11486273 |doi=10.1007/s002510100339 |s2cid=21846867 }}
  • {{cite journal |vauthors=Liang Y, Tedder TF |title=Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. |journal=Genomics |volume=72 |issue= 2 |pages= 119–27 |year= 2001 |pmid= 11401424 |doi= 10.1006/geno.2000.6472 }}

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{{Other cell membrane proteins}}

{{gene-11-stub}}