MSC

• Message Sequence Chart
• Microelectronics Support Centre of UK Rutherford Appleton Laboratory
• MIDI Show Control
• Mouse Systems Corporation, a former manufacturer of computer mouses
• MSC Malaysia (formerly known as Multimedia Super Corridor)
• USB mass storage device class (USB MSC)
• Mobile Switching Center, of a phone network
• Management saved console

• Managed service company, a UK company structure
• Metric Systems Corporation
• Mediterranean Shipping Company
• MSC Air Cargo, cargo airline owned by Mediterranean Shipping Company
• MSC Industrial Direct, formerly Manhattan Supply Company
• MSC Software, simulation software company, formerly MacNeal-Schwendler Corporation
• Mabuhay Satellite Corporation, a defunct Philippine aerospace company

• Master of Science, usually MSc or M.Sc.
• Mastère en sciences, French degree
• Memorial Student Center, Texas A&M University, US
• Mesa State College, Colorado, United States
• Mount Saint Charles Academy, Catholic school in Rhode Island, United States
• Munsang College, Hong Kong
• Marinduque State College, Philippines, now Marinduque State University

• Medical Service Corps, of the US military forces
• Military Sealift Command, US Navy
• Military Staff Committee, United Nations body
• Munich Security Conference, annual international security conference
• A US Navy hull classification symbol: Minesweeper, coastal (MSC)

• Marianites of Holy Cross
• Missionaries of the Sacred Heart

• Maryland Science Center
• Miles of Standard Cable, former telephony unit of loss
• Manned Spacecraft Center, later Johnson Space Center
• Mathematics Subject Classification
• Messinian salinity crisis, a geological event during which the Mediterranean Sea dried up
• Meteorological Service of Canada

• Mechanosensitive channels
• Mesenchymal stem cell, a multipotent stromal cell
• MSC (gene), a human gene encoding the protein musculin
• Mammary secretory carcinoma, a rare form of the breast cancers

• Maritime Safety Committee, a United Nations body
• Marine Safety Center, a United States Coast Guard unit
• Marine Stewardship Council, concerned with sustainable fishing
• Manchester Ship Canal, England
• Mediterranean Shipping Company, a container shipping company and its subsidiaries:
• MSC Cruises, a cruise line

• Michael Schumacher's abbreviation used in Formula 1
• Metro Suburban Conference, athletic conference, Illinois, US
• Mid-South Conference, US athletic conference
• Mobile Legends: Bang Bang Mid Season Cup, annual international MLBB esports tournament
• Mobile Legends: Bang Bang Southeast Asia Cup, former tournament for regional Southeast Asia during 2017–2023
• Mohammedan Sporting Club (Dhaka), Bangladesh
• Mohammedan Sporting Club (Chittagong), a branch in Chittagong
• Mohammedan Sporting Club (Kolkata)
• Mombasa Sports Club, Kenya

• Air Cairo (ICAO designator), Egyptian airline
• Falcon Field (Arizona) (IATA code: MSC), airport in Mesa, Arizona, USA
• Mail services center
• Manpower Services Commission, a British government agency, 1974–1987
• Matthews Southern Comfort, a country rock/folk rock band
• Meritorious Service Cross, a Canadian decoration bestowed by the Monarch
• Metropolitan Special Constabulary, London, England
• Motorcycle Stability Control, an ABS variant
• Movimiento Scout Católico (Catholic Scout Movement), Spain

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