MSMO1

Sterol-C4-methyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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• {{cite journal |vauthors=Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM |title=Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations |journal=J. Lipid Res. |volume=49 |issue=12 |pages=2582–9 |year=2008 |pmid=18660489 |doi=10.1194/jlr.M800232-JLR200 |doi-access=free }}
• {{cite journal |vauthors=He M, Kratz LE, Michel JJ, Vallejo AN, Ferris L, Kelley RI, Hoover JJ, Jukic D, Gibson KM, Wolfe LA, Ramachandran D, Zwick ME, Vockley J |title=Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay |journal=J. Clin. Invest. |volume=121 |issue=3 |pages=976–84 |year=2011 |pmid=21285510 |pmc=3049385 |doi=10.1172/JCI42650 }}
• {{cite journal |vauthors=Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, Doumatey A, Huang H, Ramos E, Erdos M, Gerry N, Herbert A, Christman M, Rotimi C |title=Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans |journal=Hum. Mol. Genet. |volume=21 |issue=20 |pages=4530–6 |year=2012 |pmid=22791750 |pmc=3459464 |doi=10.1093/hmg/dds282 }}

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