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MST1R

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.{{cite journal |vauthors=Ronsin C, Muscatelli F, Mattei MG, Breathnach R | title = A novel putative receptor protein tyrosine kinase of the met family | journal = Oncogene | volume = 8 | issue = 5 | pages = 1195–202 |date=May 1993 | pmid = 8386824 }}{{cite web | title = Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4486}} MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.{{cite journal |vauthors=Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM | title = RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP | journal = EMBO J. | volume = 13 | issue = 15 | pages = 3524–32 |date=August 1994 | pmid = 8062829 | pmc = 395256 | doi = 10.1002/j.1460-2075.1994.tb06659.x}}

Interactions

MST1R has been shown to interact with Grb2.{{cite journal |vauthors=Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T | title = Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor | journal = Biochem. Biophys. Res. Commun. | volume = 216 | issue = 1 | pages = 110–8 |date=November 1995 | pmid = 7488076 | doi = 10.1006/bbrc.1995.2598 | url = https://zenodo.org/record/1229468 }}{{cite journal |vauthors=Iwama A, Yamaguchi N, Suda T | title = STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family | journal = EMBO J. | volume = 15 | issue = 21 | pages = 5866–75 |date=November 1996 | pmid = 8918464 | pmc = 452340 | doi = 10.1002/j.1460-2075.1996.tb00973.x}}

References

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Further reading

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  • {{cite journal |vauthors=Li BQ, Wang MH, Kung HF, etal |title=Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 1 |pages= 110–8 |year= 1995 |pmid= 7488076 |doi= 10.1006/bbrc.1995.2598 |url=https://zenodo.org/record/1229468 }}
  • {{cite journal |vauthors=Wang MH, Ronsin C, Gesnel MC, etal |title=Identification of the ron gene product as the receptor for the human macrophage stimulating protein |journal=Science |volume=266 |issue= 5182 |pages= 117–9 |year= 1994 |pmid= 7939629 |doi=10.1126/science.7939629 |bibcode=1994Sci...266..117W }}
  • {{cite journal |vauthors=Gaudino G, Follenzi A, Naldini L, etal |title=RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP |journal=EMBO J. |volume=13 |issue= 15 |pages= 3524–32 |year= 1994 |pmid= 8062829 |doi= 10.1002/j.1460-2075.1994.tb06659.x| pmc=395256 }}
  • {{cite journal |vauthors=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 }}
  • {{cite journal |vauthors=Collesi C, Santoro MM, Gaudino G, Comoglio PM |title=A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5518–26 |year= 1996 |pmid= 8816464 |doi= 10.1128/MCB.16.10.5518| pmc=231551 }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Iwama A, Yamaguchi N, Suda T |title=STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family |journal=EMBO J. |volume=15 |issue= 21 |pages= 5866–75 |year= 1997 |pmid= 8918464 |doi= 10.1002/j.1460-2075.1996.tb00973.x| pmc=452340 }}
  • {{cite journal |vauthors=Sakamoto O, Iwama A, Amitani R, etal |title=Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility |journal=J. Clin. Invest. |volume=99 |issue= 4 |pages= 701–9 |year= 1997 |pmid= 9045873 |doi=10.1172/JCI119214 | pmc=507853 }}
  • {{cite journal |vauthors=Follenzi A, Bakovic S, Gual P, etal |title=Cross-talk between the proto-oncogenes Met and Ron |journal=Oncogene |volume=19 |issue= 27 |pages= 3041–9 |year= 2000 |pmid= 10871856 |doi= 10.1038/sj.onc.1203620 |doi-access= free }}
  • {{cite journal |vauthors=Chen YQ, Zhou YQ, Fisher JH, Wang MH |title=Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo |journal=Oncogene |volume=21 |issue= 41 |pages= 6382–6 |year= 2002 |pmid= 12214279 |doi= 10.1038/sj.onc.1205783 |doi-access= free }}
  • {{cite journal |vauthors=Chen YQ, Zhou YQ, Fu LH, etal |title=Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais |journal=Carcinogenesis |volume=23 |issue= 11 |pages= 1811–9 |year= 2002 |pmid= 12419829 |doi=10.1093/carcin/23.11.1811 |doi-access=free }}
  • {{cite journal |vauthors=Zhou YQ, He C, Chen YQ, etal |title=Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential |journal=Oncogene |volume=22 |issue= 2 |pages= 186–97 |year= 2003 |pmid= 12527888 |doi= 10.1038/sj.onc.1206075 |doi-access= free }}
  • {{cite journal |vauthors=Danilkovitch-Miagkova A, Duh FM, Kuzmin I, etal |title=Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4580–5 |year= 2003 |pmid= 12676986 |doi= 10.1073/pnas.0837136100 | pmc=153598 |bibcode=2003PNAS..100.4580D |doi-access=free }}
  • {{cite journal |vauthors=Rampino T, Gregorini M, Soccio G, etal |title=The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma |journal=Am. J. Surg. Pathol. |volume=27 |issue= 6 |pages= 779–85 |year= 2003 |pmid= 12766581 |doi=10.1097/00000478-200306000-00008 |s2cid=21112098 }}
  • {{cite journal |vauthors=Penengo L, Rubin C, Yarden Y, Gaudino G |title=c-Cbl is a critical modulator of the Ron tyrosine kinase receptor |journal=Oncogene |volume=22 |issue= 24 |pages= 3669–79 |year= 2003 |pmid= 12802274 |doi= 10.1038/sj.onc.1206585 |doi-access= free }}
  • {{cite journal |vauthors=Maggiora P, Lorenzato A, Fracchioli S, etal |title=The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness |journal=Exp. Cell Res. |volume=288 |issue= 2 |pages= 382–9 |year= 2003 |pmid= 12915129 |doi=10.1016/S0014-4827(03)00250-7 }}
  • {{cite journal |vauthors=Santoro MM, Gaudino G, Marchisio PC |title=The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration |journal=Dev. Cell |volume=5 |issue= 2 |pages= 257–71 |year= 2003 |pmid= 12919677 |doi=10.1016/S1534-5807(03)00201-6 |doi-access=free }}
  • {{cite journal |vauthors=Angeloni D, Danilkovitch-Miagkova A, Miagkov A, etal |title=The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3726–32 |year= 2004 |pmid= 14597639 |doi= 10.1074/jbc.M309342200 |doi-access= free }}
  • {{cite journal |vauthors=van den Akker E, van Dijk T, Parren-van Amelsvoort M, etal |title=Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors |journal=Blood |volume=103 |issue= 12 |pages= 4457–65 |year= 2004 |pmid= 14982882 |doi= 10.1182/blood-2003-08-2713 |s2cid=8097946 |doi-access=free }}
  • {{cite journal |vauthors=Raeppel S, Gaudette G, etal |title=Identification of a novel series of potent RON receptor tyrosine kinase inhibitors |journal=Bioorg. Med. Chem. Lett. |volume=20 |issue= 9 |pages= 2745–9 |year= 2010 |doi= 10.1016/j.bmcl.2010.03.073 |pmid=20363625 }}

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{{Tyrosine kinases}}

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{{Growth factor receptor modulators}}

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Category:Tyrosine kinase receptors

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