MTIF2

{{Short description|Protein-coding gene in the species Homo sapiens}}

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.{{cite journal |vauthors=Bonner DS, Wiley JE, Farwell MA | title = Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids | journal = Cytogenet Cell Genet | volume = 83 | issue = 1–2 | pages = 80–1 |date=Mar 1999 | pmid = 9925935 | doi =10.1159/000015133 | s2cid = 23290955 }}{{cite journal |vauthors=Ma L, Spremulli LL | title = Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA | journal = J Biol Chem | volume = 270 | issue = 4 | pages = 1859–65 |date=Feb 1995 | pmid = 7829522 | doi =10.1074/jbc.270.4.1859 | doi-access = free }}{{cite web | title = Entrez Gene: MTIF2 mitochondrial translational initiation factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4528}}

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.

References

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{{cite journal |vauthors=Overman RG, Enderle PJ, Farrow JM, etal |title=The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene |journal=Biochim. Biophys. Acta |volume=1628 |issue= 3 |pages= 195–205 |year= 2003 |pmid= 12932832 |doi= 10.1016/s0167-4781(03)00144-1}}
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{{cite journal |vauthors=Miura E, Kato Y, Matsushima R, etal |title=The Balance between Protein Synthesis and Degradation in Chloroplasts Determines Leaf Variegation in Arabidopsis yellow variegated Mutants |journal=Plant Cell |volume=19 |issue= 4 |pages= 1313–28 |year= 2007 |pmid= 17416734 |doi= 10.1105/tpc.106.049270 | pmc=1913758 }}

MTIF2

References

Further reading