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MTUS1

{{Short description|Mammalian protein found in Homo sapiens}}

{{Infobox_gene}}

Mitochondrial tumor suppressor 1 (MTSG1) or Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor protein encoded by the MTUS1 gene in humans.{{cite journal | vauthors = Kara M, Kaplan M, Bozgeyik I, Ozcan O, Celik OI, Bozgeyik E, Yumrutas O | title = MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer | journal = Gene | volume = 587 | issue = 2 | pages = 173–7 | date = August 2016 | pmid = 27155522 | doi = 10.1016/j.gene.2016.05.006 }}{{cite journal | vauthors = Bozgeyik I, Yumrutas O, Bozgeyik E | title = MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis | journal = Gene | volume = 626 | pages = 54–63 | date = August 2017 | pmid = 28499941 | doi = 10.1016/j.gene.2017.05.019 }} Expression levels of MTUS1 was reported to be lost in various types of human malignancies such as colon, ovarian, head-and-neck, pancreas, breast cancers, bladder, gastric, and lung cancers.{{cite journal | vauthors = Bozgeyik I, Yumrutas O, Bozgeyik E | title = MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis | journal = Gene | volume = 626 | pages = 54–63 | date = August 2017 | pmid = 28499941 | doi = 10.1016/j.gene.2017.05.019 }}{{cite journal | vauthors = Ozcan O, Kara M, Yumrutas O, Bozgeyik E, Bozgeyik I, Celik OI | title = MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations | journal = Tumour Biology | volume = 37 | issue = 5 | pages = 6637–45 | date = May 2016 | pmid = 26643896 | doi = 10.1007/s13277-015-4550-4 | s2cid = 25574850 }}

Proteins encoded by MTUS1

As a result of alternative splicing MTUS1 was shown to encode 5 different protein isoforms as listed as ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4. ATIP3a and ATIP3b was generally considered as ATIP3 and ATIP1 and ATIP3 is the major splice variants encoded by MTUS1 gene.{{cite journal | vauthors = Bozgeyik I, Yumrutas O, Bozgeyik E | title = MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis | journal = Gene | volume = 626 | pages = 54–63 | date = August 2017 | pmid = 28499941 | doi = 10.1016/j.gene.2017.05.019 }}

Function

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotensin II receptor type 2 (AT2) and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.{{cite web | title = Entrez Gene: MTUS1 mitochondrial tumor suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57509 }}

Interactions

MTUS1 has been shown to interact with Angiotensin II receptor type 2.{{cite journal | vauthors = Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C | title = Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28989–97 | date = July 2004 | pmid = 15123706 | doi = 10.1074/jbc.M403880200 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C | title = Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma | journal = Molecular and Cellular Endocrinology | volume = 252 | issue = 1–2 | pages = 207–15 | date = June 2006 | pmid = 16650523 | doi = 10.1016/j.mce.2006.03.014 | s2cid = 19420252 }}
  • {{cite journal | vauthors = Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B | title = Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk | journal = Carcinogenesis | volume = 28 | issue = 7 | pages = 1442–5 | date = July 2007 | pmid = 17301065 | doi = 10.1093/carcin/bgm033 | doi-access = free }}
  • {{cite journal | vauthors = Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C | title = Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP | journal = Gene | volume = 380 | issue = 2 | pages = 127–36 | date = October 2006 | pmid = 16887298 | doi = 10.1016/j.gene.2006.05.021 }}
  • {{cite journal | vauthors = Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C | title = Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28989–97 | date = July 2004 | pmid = 15123706 | doi = 10.1074/jbc.M403880200 | doi-access = free }}

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