MUPCDH
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene.{{cite journal |vauthors=Paris MJ, Williams BR | title = Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5 | journal = Genomics | volume = 69 | issue = 2 | pages = 196–202 |date=Jan 2001 | pmid = 11031102 | doi = 10.1006/geno.2000.6339 }}{{cite journal |vauthors=Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q | title = mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains | journal = J Biol Chem | volume = 275 | issue = 32 | pages = 24622–9 |date=Sep 2000 | pmid = 10801787 | doi = 10.1074/jbc.M000234200 | s2cid = 42493271 | doi-access = free }}{{cite web | title = Entrez Gene: MUCDHL mucin and cadherin-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53841}}
This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternative splicing has been identified, with observed variation resulting in the presence or absence of domains. In addition, splicing occurs in the 5' UTR but transcripts including these variations have not been described completely.
References
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Further reading
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- {{cite journal |vauthors=Yagi T, Takeichi M |title=Cadherin superfamily genes: functions, genomic organization, and neurologic diversity |journal=Genes Dev. |volume=14 |issue= 10 |pages= 1169–80 |year= 2000 |pmid= 10817752 |doi= 10.1101/gad.14.10.1169 |s2cid=44844497 |doi-access=free }}
- {{cite journal | author=Goldberg M |title=Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 3 |pages= F454–63 |year= 2002 |pmid= 12167596 |doi= 10.1152/ajprenal.00012.2002 |name-list-style=vanc| author2=Wei M | author3=Tycko B | display-authors=3 | last4=Falikovich | first4=I | last5=Warburton | first5=D |s2cid=615952 }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Goldberg M |title=Biallelic expression of HRAS and MUCDHL in human and mouse |journal=Hum. Genet. |volume=112 |issue= 4 |pages= 334–42 |year= 2003 |pmid= 12589428 |doi= 10.1007/s00439-003-0907-7 |name-list-style=vanc| author2=Wei M | author3=Yuan L | display-authors=3 | last4=Murty | first4=VV | last5=Tycko | first5=B |s2cid=1143721 }}
- {{cite journal | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |name-list-style=vanc| author2=Gurney AL | author3=Abaya E | display-authors=3 | last4=Baker | first4=K | last5=Baldwin | first5=D | last6=Brush | first6=J | last7=Chen | first7=J | last8=Chow | first8=B | last9=Chui | first9=C }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki |s2cid=21903526 | doi-access=free }}
- {{cite journal | author=Liu T |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 |name-list-style=vanc| author2=Qian WJ | author3=Gritsenko MA | display-authors=3 | last4=Camp | first4=David G. | last5=Monroe | first5=Matthew E. | last6=Moore | first6=Ronald J. | last7=Smith | first7=Richard D. }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
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