MXRA5
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.{{cite web | title = Entrez Gene: Matrix-remodelling associated 5 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=25878 | access-date = 2012-07-24 }}
Function
This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.
Clinical relevance
Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.{{cite journal | vauthors = Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M | title = Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients | journal = Carcinogenesis | volume = 33 | issue = 9 | pages = 1797–805 | date = Sep 2012 | pmid = 22696596 | doi = 10.1093/carcin/bgs210 | pmc = 3514907 }}
References
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Further reading
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- {{cite journal | vauthors = Chondrogianni N, ((de C M Simoes D)), Franceschi C, Gonos ES | title = Cloning of differentially expressed genes in skin fibroblasts from centenarians | journal = Biogerontology | volume = 5 | issue = 6 | pages = 401–9 | year = 2004 | pmid = 15609104 | doi = 10.1007/s10522-004-3188-1 | s2cid = 20230806 }}
- {{cite journal | vauthors = Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL | title = Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes | journal = Genomics | volume = 84 | issue = 1 | pages = 205–10 | date = Jul 2004 | pmid = 15203218 | doi = 10.1016/j.ygeno.2004.01.011 }}
- {{cite journal | vauthors = Zou TT, Selaru FM, Xu Y, Shustova V, Yin J, Mori Y, Shibata D, Sato F, Wang S, Olaru A, Deacu E, Liu TC, Abraham JM, Meltzer SJ | title = Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon | journal = Oncogene | volume = 21 | issue = 31 | pages = 4855–62 | date = Jul 2002 | pmid = 12101425 | doi = 10.1038/sj.onc.1205613 | doi-access = | s2cid = 11031338 }}
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