MYCL

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.{{cite journal | vauthors = Speleman F, Van Camp G, Van Roy N | title = Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 72 | issue = 2–3 | pages = 189–190 | date = Jan 1997 | pmid = 8978772 | doi = 10.1159/000134185 }}{{cite web | title = Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4610}}

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.{{cite journal | vauthors = Ikegaki N, Minna J, Kennett RH | title = The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences | journal = EMBO J. | volume = 8 | issue = 6 | pages = 1793–9 | year = 1989 | pmid = 2548855 | pmc = 401025 | doi = 10.1002/j.1460-2075.1989.tb03573.x}}

Interactions

MYCL1 has been shown to interact with MAX.{{cite journal | vauthors = Blackwood EM, Eisenman RN | title = Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc | journal = Science | volume = 251 | issue = 4998 | pages = 1211–1217 | date = Mar 1991 | pmid = 2006410 | doi = 10.1126/science.2006410 | bibcode = 1991Sci...251.1211B }}{{cite journal | vauthors = FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE | title = Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc | journal = Oncogene | volume = 18 | issue = 15 | pages = 2489–2498 | date = Apr 1999 | pmid = 10229200 | doi = 10.1038/sj.onc.1202611 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Lüscher B | title = Function and regulation of the transcription factors of the Myc/Max/Mad network | journal = Gene | volume = 277 | issue = 1–2 | pages = 1–14 | year = 2001 | pmid = 11602341 | doi = 10.1016/S0378-1119(01)00697-7 }}
  • {{cite journal | vauthors = Ikegaki N, Minna J, Kennett RH | title = The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences | journal = EMBO J. | volume = 8 | issue = 6 | pages = 1793–9 | year = 1989 | pmid = 2548855 | pmc = 401025 | doi = 10.1002/j.1460-2075.1989.tb03573.x}}
  • {{cite journal | vauthors = Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J | title = Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing | journal = Mol. Cell. Biol. | volume = 8 | issue = 1 | pages = 186–95 | year = 1988 | pmid = 2827002 | pmc = 363100 | doi = 10.1128/mcb.8.1.186}}
  • {{cite journal | vauthors = De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J | title = The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs | journal = Mol. Cell. Biol. | volume = 8 | issue = 10 | pages = 4381–8 | year = 1988 | pmid = 3054516 | pmc = 365511 | doi = 10.1128/mcb.8.10.4381}}
  • {{cite journal | vauthors = DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW | title = The human myc gene family: structure and activity of L-myc and an L-myc pseudogene | journal = Genes Dev. | volume = 1 | issue = 10 | pages = 1311–1326 | year = 1988 | pmid = 3322939 | doi = 10.1101/gad.1.10.1311 | doi-access = free }}
  • {{cite journal | vauthors = Atchley WR, Fitch WM | title = Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 22 | pages = 10217–10221 | year = 1995 | pmid = 7479755 | pmc = 40767 | doi = 10.1073/pnas.92.22.10217 | bibcode = 1995PNAS...9210217A | doi-access = free }}
  • {{cite journal | vauthors = FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE | title = Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc | journal = Oncogene | volume = 18 | issue = 15 | pages = 2489–2498 | year = 1999 | pmid = 10229200 | doi = 10.1038/sj.onc.1202611 | doi-access = free }}
  • {{cite journal | vauthors = Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K | title = L-myc genotype is associated with different susceptibility to lung cancer in smokers | journal = Jpn. J. Cancer Res. | volume = 93 | issue = 1 | pages = 1–5 | year = 2002 | pmid = 11802801 | doi = 10.1111/j.1349-7006.2002.tb01193.x | pmc = 5926866 }}
  • {{cite journal | vauthors = Suzuki H, Yamashiro K | title = L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma | journal = Oncol. Rep. | volume = 9 | issue = 2 | pages = 345–7 | year = 2002 | pmid = 11836605 | doi = 10.3892/or.9.2.345 }}
  • {{cite journal | vauthors = Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF | title = Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ | journal = Oncol. Rep. | volume = 9 | issue = 3 | pages = 551–5 | year = 2002 | pmid = 11956626 | doi = 10.3892/or.9.3.551 }}
  • {{cite journal | vauthors = Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA | title = MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis | journal = J. Cell. Mol. Med. | volume = 6 | issue = 2 | pages = 215–222 | year = 2003 | pmid = 12169206 | doi = 10.1111/j.1582-4934.2002.tb00188.x | pmc = 6740283 }}
  • {{cite journal | vauthors = Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR | title = Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas | journal = Am. J. Pathol. | volume = 162 | issue = 5 | pages = 1603–10 | year = 2003 | pmid = 12707044 | pmc = 1851191 | doi = 10.1016/S0002-9440(10)64294-0 }}
  • {{cite journal | vauthors = Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N | title = Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer | journal = Clin. Cancer Res. | volume = 10 | issue = 5 | pages = 1758–1763 | year = 2004 | pmid = 15014029 | doi = 10.1158/1078-0432.CCR-0779-3 | doi-access = free }}
  • {{cite journal|author-link30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }}
  • {{cite journal | vauthors = Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA | title = Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival | journal = Lung Cancer | volume = 55 | issue = 3 | pages = 271–277 | year = 2007 | pmid = 17145094 | doi = 10.1016/j.lungcan.2006.10.023 | hdl = 2434/25016 | url = https://air.unimi.it/bitstream/2434/25016/2/93-Ethnic%20differences%20in%20frequencies%20of%20gene%20Lung%20cancer.pdf | hdl-access = free }}

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