MYH13
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.{{cite journal |vauthors=Winters LM, Briggs MM, Schachat F | title = The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17 | journal = Genomics | volume = 54 | issue = 1 | pages = 188–9 |date=November 1998 | pmid = 9806854 | doi = 10.1006/geno.1998.5558 }}{{cite journal |vauthors=Weiss A, Schiaffino S, Leinwand LA | title = Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity | journal = J. Mol. Biol. | volume = 290 | issue = 1 | pages = 61–75 |date=July 1999 | pmid = 10388558 | doi = 10.1006/jmbi.1999.2865 }}
Function
MYH13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement.{{cite journal |vauthors=Winters LM, Briggs MM, Schachat F | title = The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17 | journal = Genomics | volume = 54 | issue = 1 | pages = 188–9 |date=November 1998 | pmid = 9806854 | doi = 10.1006/geno.1998.5558 }}
References
{{Reflist}}
Further reading
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- {{cite journal |vauthors=Weiss A, McDonough D, Wertman B, etal |title=Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2958–63 |year= 1999 |pmid= 10077619 |doi= 10.1073/pnas.96.6.2958|pmc=15877 |bibcode=1999PNAS...96.2958W |doi-access=free }}
- {{cite journal |vauthors=Schachat F, Briggs MM |title=Phylogenetic implications of the superfast myosin in extraocular muscles. |journal=J. Exp. Biol. |volume=205 |issue= Pt 15 |pages= 2189–201 |year= 2002 |doi=10.1242/jeb.205.15.2189 |pmid= 12110653 }}
- {{cite journal |vauthors=Trynka G, Zhernakova A, Romanos J, etal |title=Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. |journal=Gut |volume=58 |issue= 8 |pages= 1078–83 |year= 2009 |pmid= 19240061 |doi= 10.1136/gut.2008.169052 |s2cid=17111427 |url=https://research.vumc.nl/en/publications/9f0b4115-baf6-4bc6-ab6b-4fd7f23f0f0a }}
- {{cite journal |vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 |pmc=442147 }}
- {{cite journal |vauthors=Schjeide BM, McQueen MB, Mullin K, etal |title=Assessment of Alzheimer's disease case-control associations using family-based methods. |journal=Neurogenetics |volume=10 |issue= 1 |pages= 19–25 |year= 2009 |pmid= 18830724 |doi= 10.1007/s10048-008-0151-3 |pmc=2841132 }}
- {{cite journal |vauthors=Shoeman RL, Sachse C, Höner B, etal |title=Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. |journal=Am. J. Pathol. |volume=142 |issue= 1 |pages= 221–30 |year= 1993 |pmid= 8424456 |pmc=1886840 }}
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{{Cytoskeletal Proteins}}
{{gene-17-stub}}