MYL1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.{{cite journal |vauthors=Hailstones DL, Gunning PW | title = Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function | journal = Mol Cell Biol | volume = 10 | issue = 3 | pages = 1095–104 |date=Mar 1990 | pmid = 2304459 | pmc = 360973 | doi = 10.1128/mcb.10.3.1095}}{{cite journal |vauthors=Cohen-Haguenauer O, Barton PJ, Nguyen VC, Serero S, Gross MS, Jegou-Foubert C, de Tand MF, Robert B, Buckingham M, Frezal J | title = Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter | journal = Hum Genet | volume = 78 | issue = 1 | pages = 65–70 |date=Mar 1988 | pmid = 3422212 | doi =10.1007/BF00291237 | s2cid = 24782863 }}{{cite web | title = Entrez Gene: MYL1 myosin, light chain 1, alkali; skeletal, fast| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4632}}
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.
References
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Further reading
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- {{cite journal |vauthors=Kelly RG, Buckingham ME |title=Modular regulation of the MLC1F/3F gene and striated muscle diversity |journal=Microsc. Res. Tech. |volume=50 |issue= 6 |pages= 510–21 |year= 2000 |pmid= 10998640 |doi= 10.1002/1097-0029(20000915)50:6<510::AID-JEMT8>3.0.CO;2-1 |s2cid=26959819 }}
- {{cite journal | author=Seidel U |title=Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms |journal=Gene |volume=66 |issue= 1 |pages= 135–46 |year= 1988 |pmid= 2458299 |doi=10.1016/0378-1119(88)90231-4 |name-list-style=vanc| author2=Bober E | author3=Winter B | display-authors=3 | last4=Lenz | first4=S | last5=Lohse | first5=P | last6=Goedde | first6=H | last7=Grzeschik | first7=K | last8=Arnold | first8=H }}
- {{cite journal |vauthors=Seidel U, Arnold HH |title=Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle |journal=J. Biol. Chem. |volume=264 |issue= 27 |pages= 16109–17 |year= 1989 |doi=10.1016/S0021-9258(18)71593-7 |pmid= 2777779 |doi-access=free }}
- {{cite journal | author=Seidel U |title=The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3 |journal=Nucleic Acids Res. |volume=15 |issue= 12 |pages= 4989 |year= 1987 |pmid= 3601661 |doi=10.1093/nar/15.12.4989 | pmc=305934 |name-list-style=vanc| author2=Bober E | author3=Winter B | display-authors=3 | last4=Lenz | first4=Susan | last5=Lohse | first5=Peter | last6=Arnold | first6=H.H. }}
- {{cite journal |vauthors=Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ |title=A Nonerythroid Isoform of Protein 4.1R Interacts with Components of the Contractile Apparatus in Skeletal Myofibers |journal=Mol. Biol. Cell |volume=11 |issue= 11 |pages= 3805–17 |year= 2001 |pmid= 11071908 |doi= 10.1091/mbc.11.11.3805| pmc=15038 }}
- {{cite journal | author=Ballweber E |title=Interaction of ADP-ribosylated actin with actin binding proteins |journal=FEBS Lett. |volume=508 |issue= 1 |pages= 131–5 |year= 2001 |pmid= 11707283 |doi=10.1016/S0014-5793(01)03040-X |name-list-style=vanc| author2=Galla M | author3=Aktories K | display-authors=3 | last4=Yeoh | first4=Sharon | last5=Weeds | first5=Alan G. | last6=Mannherz | first6=Hans Georg |s2cid=7241702 |doi-access=free}}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD | bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-style=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija | bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
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{{Cytoskeletal proteins}}{{gene-2-stub}}