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MYL6

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.{{cite journal |vauthors=Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG | title = Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA | journal = Genomics | volume = 19 | issue = 1 | pages = 186–8 |date=Jun 1994 | pmid = 8188229 | doi = 10.1006/geno.1994.1041 }}{{cite journal |vauthors=Hailstones DL, Gunning PW | title = Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function | journal = Mol Cell Biol | volume = 10 | issue = 3 | pages = 1095–104 |date=Mar 1990 | pmid = 2304459 | pmc = 360973 | doi = 10.1128/mcb.10.3.1095}}{{cite journal |vauthors=Lenz S, Lohse P, Seidel U, Arnold HH | title = The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways | journal = J Biol Chem | volume = 264 | issue = 15 | pages = 9009–15 |date=Jun 1989 | doi = 10.1016/S0021-9258(18)81895-6 | pmid = 2722814 | doi-access = free }}

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.{{cite web | title = Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4637}}

References

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Further reading

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  • {{cite journal |vauthors=Komiyama M, Soldati T, von Arx P, Perriard JC |title=The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition |journal=J. Cell Sci. |volume=109 |issue= 8|pages= 2089–99 |year= 1997 |doi=10.1242/jcs.109.8.2089 |pmid= 8856505 |url=https://archive-ouverte.unige.ch/unige:18932 }}
  • {{cite journal |vauthors=Watanabe M, Kohri M, Takaishi M, etal |title=Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells |journal=Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi |volume=37 |issue= 1 |pages= 25–38 |year= 2001 |pmid= 11436981 |doi=10.1540/jsmr.37.25 |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |s2cid=11683986 }}
  • {{cite journal |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 |s2cid=27764390 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Fu ZY, Xie BT, Ma YT, Gong ZX |title=Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=38 |issue= 9 |pages= 625–32 |year= 2006 |pmid= 16953301 |doi=10.1111/j.1745-7270.2006.00203.x |doi-access= |s2cid=15419702 }}

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{{PDB Gallery|geneid=4637}}{{Cytoskeletal proteins}}

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