MYLIP
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.{{cite web | title = Entrez Gene: MYLIP myosin regulatory light chain interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116}}
MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation or MIR "Modulator Of Immune Recognition".{{cite journal |vauthors=Zelcer N, Hong C, Boyadjian R, Tontonoz P | title = LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor | journal = Science | volume = 325 | issue = 5936 | pages = 100–4 |date=July 2009 | pmid = 19520913 | doi = 10.1126/science.1168974 | pmc = 2777523 | bibcode = 2009Sci...325..100Z }}{{cite journal |vauthors=Lindholm D, Bornhauser BC, Korhonen L | title = Mylip makes an Idol turn into regulation of LDL receptor | journal = Cell. Mol. Life Sci. | volume = 66 | issue = 21 | pages = 3399–402 |date=November 2009 | pmid = 19688294 | doi = 10.1007/s00018-009-0127-y | s2cid = 34153384 | pmc = 11115883 }} The expression of IDOL is induced by the sterol-activated liver X receptor.
Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.{{cite journal | author = Sawamura, T. | title = New Idol for cholesterol reduction? | journal = Clin. Chem. | volume = 55 | issue = 12| pages = 2082–2084 |date= 2009 | pmid = 19833835| doi = 10.1373/clinchem.2009.134023 | doi-access = free }} Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.
Function
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
References
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Further reading
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- {{cite journal |vauthors=Olsson PA, Korhonen L, Mercer EA, Lindholm D |title=MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36288–92 |year= 2000 |pmid= 10593918 |doi=10.1074/jbc.274.51.36288 |doi-access=free }}
- {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
- {{cite journal |vauthors=Olsson PA, Bornhauser BC, Korhonen L, Lindholm D |title=Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 879–83 |year= 2001 |pmid= 11162443 |doi= 10.1006/bbrc.2000.4028 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Bornhauser BC, Olsson PA, Lindholm D |title=MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35412–20 |year= 2003 |pmid= 12826659 |doi= 10.1074/jbc.M306271200 |doi-access= free }}
- {{cite journal |vauthors=Bornhauser BC, Johansson C, Lindholm D |title=Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR. |journal=FEBS Lett. |volume=553 |issue= 1–2 |pages= 195–9 |year= 2003 |pmid= 14550572 |doi=10.1016/S0014-5793(03)01010-X |s2cid=25599548 |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 | pmc=524842 |bibcode=2004PNAS..10115724W |doi-access=free }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Ohmura-Hoshino M, Matsuki Y, Aoki M, etal |title=Inhibition of MHC class II expression and immune responses by c-MIR. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 341–54 |year= 2006 |pmid= 16785530 |doi= 10.4049/jimmunol.177.1.341|doi-access=free }}
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{{Cytoskeletal proteins}}{{gene-6-stub}}