MYLK

This gene, a muscle member of the immunoglobulin superfamily, encodes a myosin light-chain kinase, which is a calcium-/calmodulin-dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.{{cite web | title = Entrez Gene: MYLK myosin, light chain kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4638}}

• Myosin light-chain kinase

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• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
• {{cite journal |vauthors=Clayburgh DR, Rosen S, Witkowski ED, etal |title=A Differentiation-dependent Splice Variant of Myosin Light Chain Kinase, MLCK1, Regulates Epithelial Tight Junction Permeability |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55506–13 |year= 2005 |pmid= 15507455 |doi= 10.1074/jbc.M408822200 | pmc=1237105 |doi-access=free }}
• {{cite journal |vauthors=Wang F, Graham WV, Wang Y, etal |title=Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression |journal=Am. J. Pathol. |volume=166 |issue= 2 |pages= 409–19 |year= 2005 |pmid= 15681825 |doi= 10.1016/S0002-9440(10)62264-X| pmc=1237049 }}
• {{cite journal |vauthors=Russo JM, Florian P, Shen L, etal |title=Distinct Temporal-Spatial Roles for Rho Kinase and Myosin Light Chain Kinase in Epithelial Purse-String Wound Closure |journal=Gastroenterology |volume=128 |issue= 4 |pages= 987–1001 |year= 2005 |pmid= 15825080 |doi=10.1053/j.gastro.2005.01.004 | pmc=1237051 }}
• {{cite journal |vauthors=Shimizu S, Yoshida T, Wakamori M, etal |title=Ca2+–calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells |journal=J. Physiol. |volume=570 |issue= Pt 2 |pages= 219–35 |year= 2006 |pmid= 16284075 |doi= 10.1113/jphysiol.2005.097998 | pmc=1464317 }}
• {{cite journal |vauthors=Kim MT, Kim BJ, Lee JH, etal |title=Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells |journal=Am. J. Physiol., Cell Physiol. |volume=290 |issue= 4 |pages= C1031–40 |year= 2006 |pmid= 16306123 |doi= 10.1152/ajpcell.00602.2004 }}
• {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
• {{cite journal |vauthors=Connell LE, Helfman DM |title=Myosin light chain kinase plays a role in the regulation of epithelial cell survival |journal=J. Cell Sci. |volume=119 |issue= Pt 11 |pages= 2269–81 |year= 2007 |pmid= 16723733 |doi= 10.1242/jcs.02926 |doi-access= free }}
• {{cite journal |vauthors=Seguchi O, Takashima S, Yamazaki S, etal |title=A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart |journal=J. Clin. Invest. |volume=117 |issue= 10 |pages= 2812–24 |year= 2007 |pmid= 17885681 |doi= 10.1172/JCI30804 | pmc=1978424 }}

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• {{MeshName|MYLK+protein,+human}}

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{{Serine/threonine-specific protein kinases}}{{Cytoskeletal proteins}}{{Enzymes}}

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Category:EC 2.7.11

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