MYLK2

This gene encodes a myosin light chain kinase, a calcium / calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.{{cite web | title = Entrez Gene: MYLK2 myosin light chain kinase 2, skeletal muscle | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85366 }} The MYLK2 gene expresses skMLCK more prevalently in fast twitch muscle fibers as compared to slow twitch muscle fibers. Calmodulin is composed of two terminal domains (N,C) each containing two E-F hand motifs that bind to Ca2+. Upon saturation of Ca2+, Calmodulin undergoes a conformation change allowing it to bind with a target protein such as skMLCK. An image depicting a similar complex (sdCen/skMLCK2) is shown under myosin light chain kinase. This binding to skMLCK increases the affinity of Ca2+ and ultimately leads to a sustained muscle action.{{cite journal |vauthors=Stull JT, Kamm KE, Vandenboom R |title=Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle |journal=Arch Biochem Biophys |volume= 510|issue= 2|pages= 120–8|date=February 2011 |pmid=21284933 |doi=10.1016/j.abb.2011.01.017 |pmc=3101293}}

Mutations in the MYLK2 gene have been linked to midventricular hypertrophic cardiomyopathy.

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{{Serine/threonine-specific protein kinases}}{{Cytoskeletal proteins}}{{Enzymes}}

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Category:EC 2.7.11

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