MYLK3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.{{cite web | title = Entrez Gene: MLCK MLCK protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91807}}{{cite journal |vauthors=Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M | title = A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart | journal = J. Clin. Invest. | volume = 117 | issue = 10 | pages = 2812–24 |date=October 2007 | pmid = 17885681 | pmc = 1978424 | doi = 10.1172/JCI30804 }}
Function
Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.{{cite journal |vauthors=Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H | title = Identification of cardiac-specific myosin light chain kinase | journal = Circ. Res. | volume = 102 | issue = 5 | pages = 571–80 |date=March 2008 | pmid = 18202317 | pmc = 2504503 | doi = 10.1161/CIRCRESAHA.107.161687 }}
See also
References
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Further reading
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- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Clayburgh DR, Rosen S, Witkowski ED, etal |title=A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 55506–13 |year= 2005 |pmid= 15507455 |doi= 10.1074/jbc.M408822200 | pmc=1237105 |doi-access=free }}
- {{cite journal |vauthors=Wang F, Graham WV, Wang Y, etal |title=Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. |journal=Am. J. Pathol. |volume=166 |issue= 2 |pages= 409–19 |year= 2005 |pmid= 15681825 |doi= 10.1016/S0002-9440(10)62264-X| pmc=1237049 }}
- {{cite journal |vauthors=Russo JM, Florian P, Shen L, etal |title=Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. |journal=Gastroenterology |volume=128 |issue= 4 |pages= 987–1001 |year= 2005 |pmid= 15825080 |doi= 10.1053/j.gastro.2005.01.004| pmc=1237051 }}
- {{cite journal |vauthors=Shimizu S, Yoshida T, Wakamori M, etal |title=Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells. |journal=J. Physiol. |volume=570 |issue= Pt 2 |pages= 219–35 |year= 2006 |pmid= 16284075 |doi= 10.1113/jphysiol.2005.097998 | pmc=1464317 }}
- {{cite journal |vauthors=Kim MT, Kim BJ, Lee JH, etal |title=Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells. |journal=Am. J. Physiol., Cell Physiol. |volume=290 |issue= 4 |pages= C1031–40 |year= 2006 |pmid= 16306123 |doi= 10.1152/ajpcell.00602.2004 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Connell LE, Helfman DM |title=Myosin light chain kinase plays a role in the regulation of epithelial cell survival. |journal=J. Cell Sci. |volume=119 |issue= Pt 11 |pages= 2269–81 |year= 2007 |pmid= 16723733 |doi= 10.1242/jcs.02926 |doi-access= free }}
- {{cite journal |vauthors=Seguchi O, Takashima S, Yamazaki S, etal |title=A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. |journal=J. Clin. Invest. |volume=117 |issue= 10 |pages= 2812–24 |year= 2007 |pmid= 17885681 |doi= 10.1172/JCI30804 | pmc=1978424 }}
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{{NLM content}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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