MYLK4

{{short description|Enzyme in humans}}

{{infobox protein

| Name = Myosin light chain kinase family, member 4

| caption = The crystal structure of the human myosin light chain kinase Loc340156.{{cite web |url=http://www.rcsb.org/pdb/explore/explore.do?structureId=2X4F |title=RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156. }}

| image = 2X4F.pdb.png

| width =

| HGNCid = 27972

| Symbol = MYLK4

| AltSymbols =

| EntrezGene = 340156

| OMIM =

| RefSeq = NM_001012418

| UniProt = Q86YV6

| PDB =

| ECnumber = 2.7.11.18

| Chromosome = 6

| Arm = p

| Band = 25.2

| LocusSupplementaryData =

}}

Myosin light chain kinase 4 also known as MYLK4 is an enzyme which in humans is encoded by the MYLK2 gene.{{cite journal |vauthors=Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S | title = The protein kinase complement of the human genome | journal = Science | volume = 298 | issue = 5600 | pages = 1912–34 |date=December 2002 | pmid = 12471243 | doi = 10.1126/science.1075762 | bibcode = 2002Sci...298.1912M | s2cid = 26554314 }} MYLK4 is a member of the myosin light-chain kinase family of serine/threonine-specific protein kinases that phosphorylate the regulatory light chain of myosin II.{{cite journal |vauthors=Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K | title = Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction | journal = IUBMB Life | volume = 51 | issue = 6 | pages = 337–44 |date=June 2001 | pmid = 11758800 | doi = 10.1080/152165401753366087| s2cid = 46180993 | doi-access = free }}

This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.{{cite web |url=http://beta.nextprot.org/db/entry/NX_Q86YV6 |archive-url=https://archive.today/20130415101110/http://beta.nextprot.org/db/entry/NX_Q86YV6 |url-status=dead |archive-date=April 15, 2013 |title=MYLK4 - Protein (Function), MYLK4 - Protein (Function) }}

MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.{{cite web |url=http://www.phosphosite.org/proteinAction.do?id=7734&showAllSites=true |title=www.phosphosite.org }}

Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer.{{cite web |url=http://www.thesgc.org/structures/structure_description/2X4F/ |title=SGC | Human Myosin Light Chain Kinase Family Member 4 (LOC340156) PDB Code: 2X4F }}

MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding.{{cite web |url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=MYLK4 |title=MYLK4 Gene - GeneCards | MYLK4 Protein | MYLK4 Antibody }}

Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085.{{cite web |url=http://www.signaling-gateway.org/molecule/query?afcsid=A003358 |title=Sgk085 : Protein Overview : UCSD Molecule Pages |access-date=2011-04-26 |archive-date=2011-07-22 |archive-url=https://web.archive.org/web/20110722064653/http://www.signaling-gateway.org/molecule/query?afcsid=A003358 |url-status=dead }}

There are other known myosin light-chain kinase enzymes.