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MZF1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.{{cite journal | vauthors = Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K | title = A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells | journal = J Biol Chem | volume = 266 | issue = 22 | pages = 14183–7 | date = September 1991 | doi = 10.1016/S0021-9258(18)98664-3 | pmid = 1860835 | doi-access = free }}{{cite web | title = Entrez Gene: MZF1 myeloid zinc finger 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7593}}

Interactions

MZF1 has been shown to interact with SCAND1.{{cite journal | vauthors = Sander TL, Haas AL, Peterson MJ, Morris JF | title = Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations | journal = J. Biol. Chem. | volume = 275 | issue = 17 | pages = 12857–12867 | date = April 2000 | pmid = 10777584 | doi = 10.1074/jbc.275.17.12857 | doi-access = free }}

In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.{{cite journal | vauthors = Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH | title = The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol | journal = Biochem. Biophys. Res. Commun. | volume = 451 | issue = 1 | pages = 137–41 | year = 2014 | pmid = 25065746 | doi = 10.1016/j.bbrc.2014.07.082 }} The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.{{cite journal|doi=10.1002/jcp.25021 | pmid=25899830 | volume=230 | issue=11 | title=Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment | journal=Journal of Cellular Physiology | pages=2634–2639 | vauthors=Piszczatowski RT| year=2015 | s2cid=6888015 | doi-access=free }}

References

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Further reading

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  • {{cite journal | vauthors = Bavisotto L, Kaushansky K, Lin N, Hromas R | title = Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro | journal = J. Exp. Med. | volume = 174 | issue = 5 | pages = 1097–1101 | year = 1991 | pmid = 1719120 | pmc = 2119006 | doi = 10.1084/jem.174.5.1097 }}
  • {{cite journal | vauthors = Sander TL, Haas AL, Peterson MJ, Morris JF | title = Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations | journal = J. Biol. Chem. | volume = 275 | issue = 17 | pages = 12857–12867 | year = 2000 | pmid = 10777584 | doi = 10.1074/jbc.275.17.12857 | doi-access = free }}
  • {{cite journal | vauthors = Peterson MJ, Morris JF | title = Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein | journal = Gene | volume = 254 | issue = 1–2 | pages = 105–118 | year = 2000 | pmid = 10974541 | doi = 10.1016/S0378-1119(00)00281-X }}
  • {{cite journal | vauthors = Takahashi K, Matsumoto C, Ra C | title = FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1 | journal = Biochem. J. | volume = 386 | issue = Pt 1 | pages = 191–200 | year = 2005 | pmid = 15453830 | pmc = 1134781 | doi = 10.1042/BJ20040775 }}
  • {{cite journal | vauthors = Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH | title = Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene | journal = Mol. Cells | volume = 18 | issue = 2 | pages = 157–62 | year = 2005 | doi = 10.1016/S1016-8478(23)13096-2 | pmid = 15528990 | doi-access = free }}
  • {{cite journal | vauthors = Le Mée S, Fromigué O, Marie PJ | title = Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts | journal = Exp. Cell Res. | volume = 302 | issue = 1 | pages = 129–142 | year = 2005 | pmid = 15541732 | doi = 10.1016/j.yexcr.2004.08.028 }}
  • {{cite journal | vauthors = Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C | title = LDOC1, a novel MZF-1-interacting protein, induces apoptosis | journal = FEBS Lett. | volume = 579 | issue = 3 | pages = 604–608 | year = 2005 | pmid = 15670815 | doi = 10.1016/j.febslet.2004.12.030 | s2cid = 30914046 | doi-access = }}
  • {{cite journal | vauthors = Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY | title = PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells | journal = Biochem. Biophys. Res. Commun. | volume = 339 | issue = 1 | pages = 217–225 | year = 2006 | pmid = 16297876 | doi = 10.1016/j.bbrc.2005.11.015 }}
  • {{cite journal | vauthors = Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF | title = Structure of the SCAN domain from the tumor suppressor protein MZF1 | journal = J. Mol. Biol. | volume = 363 | issue = 1 | pages = 137–147 | year = 2006 | pmid = 16950398 | pmc = 1941711 | doi = 10.1016/j.jmb.2006.07.063 }}
  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–648 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}

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