Macchia d'Isernia

{{Infobox Italian comune

| name = Macchia d'Isernia

| official_name = Comune di Macchia d'Isernia

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| coordinates = {{coord|41|34|N|14|10|E|type:city(930)_region:IT|display=inline,title}}

| coordinates_footnotes =

| region = Molise

| province = Isernia (IS)

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| mayor = Giovanni Martino

| area_footnotes =

| area_total_km2 = 17.71

| population_footnotes = All demographics and other statistics: Italian statistical institute Istat.

| population_total = 1008

| population_as_of = 31 August 2022

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| population_demonym = Macchiaroli

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| elevation_m = 360

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| postal_code = 86070

| area_code = 0865

| website = {{official website|http://www.comune.macchiadisernia.is.it/}}

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File:Palazzo_baronale_di_Macchia_d'Isernia.jpg

Macchia d'Isernia is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about {{convert|40|km|mi}} west of Campobasso and about {{convert|7|km|mi|0}} southwest of Isernia.

Macchia d'Isernia borders the following municipalities: Colli a Volturno, Fornelli, Isernia, Monteroduni, Sant'Agapito.