Macrophage-capping protein

{{Short description|Protein-coding gene in the species Homo sapiens}}

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.{{cite journal |vauthors=Dabiri GA, Young CL, Rosenbloom J, Southwick FS | title = Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages | journal = J Biol Chem | volume = 267 | issue = 23 | pages = 16545–52 |date=Sep 1992 | doi = 10.1016/S0021-9258(18)42037-6 | pmid = 1322908 | doi-access = free }}{{cite journal |vauthors=Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P | title = Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress | journal = J Biol Chem | volume = 278 | issue = 31 | pages = 29136–44 |date=Jul 2003 | pmid = 12754261 | doi = 10.1074/jbc.M300598200 | doi-access = free }}{{cite web | title = Entrez Gene: CAPG capping protein (actin filament), gelsolin-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=822}}

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins.{{Cite journal

| pmid = 24155256

| year = 2013

| last1 = Ghoshdastider

| first1 = U

| title = The expanding superfamily of gelsolin homology domain proteins

| journal = Cytoskeleton

| volume = 70

| issue = 11

| pages = 775–95

| last2 = Popp

| first2 = D

| last3 = Burtnick

| first3 = L. D.

| last4 = Robinson

| first4 = R. C.

| doi = 10.1002/cm.21149

| s2cid = 205643538

}} The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively, spliced transcript variants have been observed, but have not been fully described.

References

{{cite journal | author=Southwick FS |title=Gain-of-function mutations conferring actin-severing activity to human macrophage cap G |journal=J. Biol. Chem. |volume=270 |issue= 1 |pages= 45–8 |year= 1995 |pmid= 7814409 |doi= 10.1074/jbc.270.1.45 |doi-access= free }}
{{cite journal |vauthors=Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS |title=The human actin-regulatory protein cap G: gene structure and chromosome location |journal=Genomics |volume=23 |issue= 3 |pages= 560–5 |year= 1995 |pmid= 7851883 |doi= 10.1006/geno.1994.1543 }}
{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{cite journal |vauthors=Hirano T, Kobayashi R, Hirano M |title=Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein |journal=Cell |volume=89 |issue= 4 |pages= 511–21 |year= 1997 |pmid= 9160743 |doi=10.1016/S0092-8674(00)80233-0 |s2cid=15061740 |doi-access=free }}
{{cite journal |vauthors=Cabello OA, Eliseeva E, He WG, etal |title=Cell cycle-dependent expression and nucleolar localization of hCAP-H |journal=Mol. Biol. Cell |volume=12 |issue= 11 |pages= 3527–37 |year= 2002 |pmid= 11694586 |doi= 10.1091/mbc.12.11.3527| pmc=60273 }}
{{cite journal |vauthors=Van Impe K, De Corte V, Eichinger L, etal |title=The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17945–52 |year= 2003 |pmid= 12637565 |doi= 10.1074/jbc.M209946200 |doi-access= free }}
{{cite journal |vauthors=De Corte V, Van Impe K, Bruyneel E, etal |title=Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion |journal=J. Cell Sci. |volume=117 |issue= Pt 22 |pages= 5283–92 |year= 2005 |pmid= 15454578 |doi= 10.1242/jcs.01410 |doi-access= free }}
{{cite journal |vauthors=Watari A, Takaki K, Higashiyama S, etal |title=Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG |journal=Oncogene |volume=25 |issue= 56 |pages= 7373–80 |year= 2007 |pmid= 16767159 |doi= 10.1038/sj.onc.1209732 |doi-access= free }}
{{cite journal |vauthors=Chi A, Valencia JC, Hu ZZ, etal |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}

Macrophage-capping protein

Function

References

Further reading