Mad Dog

• Johnny Adair (born 1963), Northern Irish loyalist paramilitary
• Martin Allen (born 1965), English footballer
• Brett Banasiewicz (born 1994), American professional BMX rider
• Charles Brown (1933–1962), American spree killer
• Roger Caron (1938–2012), Canadian robber
• Mad Dog Coll (1908–1932), Irish-American gangster
• David C. Dolby (1946–2010), US Army Medal of Honor recipient
• Charles Gargotta (1900–1950), Italian-American gangster
• Jon Hall (programmer) (born 1950), American computer programmer
• Gene Hatcher (born 1959), American boxer
• Leslie Irvin (serial killer) (1924–1983), 1950s American serial killer
• Charles Kelley (1941–1962), American spree killer
• Bob Lassiter (1945–2006), American radio talk show host
• Vini Lopez (born 1949), American drummer
• Adam MacDougall (born 1975), Australian rugby league player
• Jeff Madden, college football strength and conditioning coach
• Bill Madlock (born 1951), American baseball player
• Mark Madsen (basketball) (born 1976), American basketball coach and former player
• Jim Mandich (1948–2011), American football player
• Jim Mattis (born 1950), American Marine Corps general and Secretary of Defense
• Archie McCafferty, Scottish-born Australian serial killer
• Brian McGlinchey (born 1977), Northern Ireland footballer
• Dominic McGlinchey (1954–1994), leader of the Irish National Liberation Army paramilitary group
• Lewis Moody (born 1978), English rugby union player
• Dan Morgan (bushranger) (1830–1865), Australian bushranger
• Robbie Muir (footballer) (born 1953), Australian rules footballer
• Edgar Ross (boxer) (1949–2012), American boxer
• Chris Russo (born 1959), American sports radio personality
• Joseph "Mad Dog" Taborsky (1924–1960), American spree killer
• Michael Taccetta (born 1947), American mobster
• Dwight White (1949–2008), American football player
• Xu Xiaodong (born 1979), Chinese mixed martial artist
• Wong Yuk-man (born 1951), Hong Kong politician

• Mike Bell (wrestler) (1971–2008), American professional wrestler
• Pierre Lefebvre (1955–1985), French-Canadian professional wrestler
• Michel Martel (1944–1978), Canadian professional wrestler
• Mad Dog McPhie (born 1971), English professional wrestler
• Mad Dog O'Malley, Irish-American professional wrestler
• Maurice Vachon (1929–2013), French-Canadian professional wrestler

• Mad Dog (comics), various characters
• Mad Dog (Marvel Comics), a villain
• Mad Dog Rassitano, a bounty hunter in the Marvel Universe
• Buford "Mad Dog" Tannen, from the film Back to the Future Part III
• the title character of Johnny Mad Dog, a 2008 film
• Mad Dog, a character from manga and anime series Haikyu!!
• Mad Dog Branzillo, in the book A Swiftly Tilting Planet by Madeleine L'Engle
• Mad Dog, nickname of Wayne Dobie in the film Mad Dog and Glory
• Mad Dog, from the film Hard Boiled, played by Philip Kwok
• Mad Dog, from the film Ong Bak, played by David Ismalone
• Mad Dog, from the film The Raid: Redemption, played by Yayan Ruhian
• the title character of Mad Dog Morgan, a 1976 Australian bushranger film
• Tommy "Mad Dog" McCulum, from the South African TV series Isidingo
• the title character of Mad Dog McCree, a 1990 laserdisc video game
• Mad Dog, in the Nintendo DS game Contra 4
• Madd Dogg, in the 2004 video game Grand Theft Auto: San Andreas

• Mad Dog (album), by John Entwistle
• "Mad Dog", a song from the album Holiday by America
• "Mad Dog", a song from the album The House of Blue Light by Deep Purple
• "Mad Dog", a song from the album Sub-Basement by Pentagram

• Mad Dog (TV series), a 2017 South Korean television series
• "Mad Dog", an episode of the 1975 television series Survivors
• Mad Dog Knives, a knifemaking company
• Mad Dog Oil Field, in the Gulf of Mexico
• Mad Dog Inc., a group of Texas authors including Bud Shrake
• MD 20/20, nicknamed 'Mad Dog', a flavored fortified wine from Mogen David
• MadDog, the mascot of the Northeastern University Rugby Club
• McDonnell Douglas MD-80, a family of commercial jet liners nicknamed Mad Dog

• The mad dog of the Middle East, a phrase used by U.S. President Ronald Reagan to describe Libyan leader Muammar Gaddafi
• Wanderlei Silva (born 1976), Brazilian mixed martial artist nicknamed Cachorro Louco (Portuguese for "mad dog")
• Mad-dog skullcap (Scutellaria lateriflora), a plant
• Mad Dog Coll (disambiguation)
• Mad Dogs (disambiguation)
• Mad Dogs and Englishmen (disambiguation)
• {{intitle|Mad Dog}}
• Goro Majima, known as the "Mad Dog of Shimano" in the Yakuza video game series
• Wściekły pies (English: mad dog), Polish cocktail

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