Malakoplakia
{{Infobox medical condition (new)
| name = Malakoplakia
| synonyms = Malacoplakia
| image = Michaelis-Gutmann bodies - very high mag - cropped.jpg
| caption = Micrograph showing the characteristic finding of malakoplakia (Michaelis–Gutmann bodies). H&E stain.
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Malakoplakia (from Greek Malako "soft" + Plako "plaque") is a rare inflammatory condition which makes its presence known as a papule, plaque or ulceration that usually affects the genitourinary tract.{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: clinical Dermatology |publisher=Saunders Elsevier |year=2006 |isbn=978-0-7216-2921-6 |display-authors=etal}}{{rp|274}} However, it may also be associated with other bodily organs. It was initially described in the early 20th century as soft yellowish plaques found on the mucosa of the urinary bladder. Microscopically it is characterized by the presence of foamy histiocytes (called von Hansemann cells) with basophilic inclusions called Michaelis–Gutmann bodies.
It usually involves gram-negative bacteria.{{cite book|author1=Liang Cheng|author2=David G. Bostwick|title=Essentials of anatomic pathology|url=https://books.google.com/books?id=B-LUwWcqspoC&pg=PA1180|access-date=15 May 2010|year=2006|publisher=Springer|isbn=978-1-58829-461-6|pages=1180–}}
Causes
Malakoplakia is thought to result from the insufficient killing of bacteria by macrophages. Therefore, the partially digested bacteria accumulate in macrophages leading to deposition of iron and calcium. The impairment of bactericidal activity manifests itself as the formation of an ulcer, plaque or papule. Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma, diabetes mellitus, kidney transplantation, or because of long-term therapy with systemic corticosteroids.{{citation needed|date=September 2020}}
Diagnosis
As malakoplakia is a condition associated with chronic cystitis, it usually presents itself as a cystitis condition. The following investigations may help in making the diagnosis of malakoplakia:{{citation needed|date=July 2020}}
- Urinalysis which indicates presence of bacteria and white blood cells.
- Urine culture
- Cystoscopic evaluation confirms presence of ulcer or papule.
- Biopsy to rule out other causes.
- The presence of large multinucleated malakoplakia giant cells with concretions called as Michaelis Gutman bodies on microscopy.
Treatment
Treatments for malakoplakia include catheterizing the affected person with full aseptic precautions. Additionally, irrigating the bladder with distilled water three times daily with 3 way Foley's catheter and urinary antiseptics like pyridium may be used to help relieve urinary symptoms. Antibiotics such as trimethoprim-sulfamethoxazole or ciprofloxacin may be used.{{cite journal |last1=Simpson |first1=Claire |last2=Strong |first2=Nicholas P. |last3=Dickinson |first3=Jane |last4=Young |first4=Fergus I. |last5=Sandford-Smith |first5=John H. |title=Medical Management of Ocular Malakoplakia |journal=Ophthalmology |date=February 1992 |volume=99 |issue=2 |pages=192–196 |doi=10.1016/s0161-6420(92)31993-1 |pmid=1553207 }}{{cite journal |last1=van Furth |first1=R. |last2=van't Wout |first2=J.W. |last3=Zwartendijk |first3=J. |last4=Wertheimer |first4=P.A. |title=Ciprofloxacin for treatment of malakoplakia |journal=The Lancet |date=January 1992 |volume=339 |issue=8786 |pages=148–149 |doi=10.1016/0140-6736(92)90212-l |pmid=1346012 |s2cid=1436404 }}
History
Leonor Michaelis and Carl Gutmann first described malakoplakia in 1902 after analyzing a patient's tumor at the request of David Paul von Hansemann.{{cite journal |vauthors=McClure J |title=Malakoplakia |journal=J Pathol |volume=140 |issue=4 |pages=275–330 |date=August 1983 |pmid=6308195 |doi=10.1002/path.1711400402 |s2cid=222083065 }}
See also
References
External links
{{Medical resources
| DiseasesDB = 29128
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| eMedicineSubj = derm
| eMedicineTopic = 872
| MeshID = D008287
| Orphanet = 556
| SNOMED CT = 716766007
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{{Urinary tract disease}}
{{Bacterial cutaneous infections}}
Category:Urological conditions