Malcolm Stevens
{{short description|English chemist and professor}}
{{for|the footballer|Malcolm Stephens}}
{{Use dmy dates|date=February 2020}}
{{EngvarB|date=February 2020}}
{{Infobox person
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| name = Malcolm Stevens
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| birth_name = Malcolm Francis Graham Stevens
| birth_date = {{Birth year and age|1938}}
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| citizenship = British
| education = Bolton School
| alma_mater = University of Nottingham
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| spouse = Valerie Deans (m.1961)
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Malcolm Francis Graham Stevens is an English chemist and Emeritus professor of the University of Nottingham, having previously worked at Aston University where he developed the cancer drug temozolomide.{{cite web|title=Malcolm Stevens|url=https://www.nottingham.ac.uk/pharmacy/people/malcolm.stevens|website=School of Pharmacy|publisher=University of Nottingham|accessdate=5 September 2017}}
Education and family
Stevens attended Bolton School, Lancashire, and then obtained a BSc and PhD at the University of Nottingham.{{cite web|title=100 Inspiring Minds – Professor Malcolm Stevens OBE, FRS|url=https://boltonschool100500.org/100-inspiring-minds-professor-malcolm-stevens-obe-frs/|publisher=Bolton School|accessdate=5 September 2017|archive-url=https://web.archive.org/web/20170906181514/https://boltonschool100500.org/100-inspiring-minds-professor-malcolm-stevens-obe-frs/|archive-date=6 September 2017|url-status=dead}}
He married Valerie Deans at Christ Church, Heaton, Bolton, in 1961.{{Cite web|url=https://www.freebmd.org.uk/cgi/information.pl?r=223676468:9511&d=bmd_1503998064|title=Marriage index entry|date=September 1961|accessdate=6 September 2017|work=FreeBMD|publisher=ONS}}{{Cite web|url=http://www.lancashirebmd.org.uk/marriages.php|title=Marriage Indexes|accessdate=6 September 2017|website=lancashirebmd.org.uk}}
Career
Stevens took up a post of Reader in the Department of Pharmaceutical Sciences at Aston University in 1972, and was later appointed Professor. He was a member of the Cancer Research UK Experimental Cancer Chemotherapy group from 1980 to 2006, moving to the University of Nottingham in 1992.{{cite web|title=Professor Malcolm Stevens OBE, FRS|url=http://www.aston.ac.uk/50/50-aston-greats/malcolm-stevens/|website=50 Aston Greats|publisher=Aston University|accessdate=5 September 2017}}
Stevens's lab synthesised Temozolomide, which as of 2019, remains the only FDA-approved drug to treat the deadly brain tumor Glioblastoma multiforme. Temozolomide has had a substantial impact in the clinic: the 5-year survival with radiation alone is 4%, whilst with radiation plus temozolomide, it approaches 17%. The 10 year survival without temozolomide is <1% versus around 8% with temozolomide. Thus, long term survivorship with GBM is now possible (if not common), thanks to the work of Stevens and his group.{{cite journal |last1=Weller |first1=Michael|display-authors=etal |title=How we treat glioblastoma |journal=ESMO Open |date=17 June 2019 |volume=4 |issue=Suppl 2 |pages=e000520 |doi=10.1136/esmoopen-2019-000520|pmid=31297242|pmc=6586206}}{{cite journal |last1=Stupp |first1=Roger|display-authors=etal |title=Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma |journal=New England Journal of Medicine |date=10 March 2005 |volume=352 |issue=10 |pages=987–996 |doi=10.1056/NEJMoa043330 |pmid=15758009|url=https://serval.unil.ch/notice/serval:BIB_DEA725BDEE44|doi-access=free }}
Recognition
Stevens was appointed OBE in the 1999 New Year Honours "For services to the development of Cancer Drugs", being described as "Professor of Experimental Cancer Chemotherapy,
University of Nottingham".{{London Gazette |issue=55354 |date=31 December 1998 |page= 13|supp= y}} He was elected a Fellow of the Royal Society in 2009.{{cite web|title=Malcolm Stevens|url=https://royalsociety.org/people/malcolm-stevens-12346/|publisher=The Royal Society|accessdate=5 September 2017}}
References
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External links
- {{cite web | url=http://scienceblog.cancerresearchuk.org/professor-malcolm-stevens-the-story-of-temozolomide-video-transcript/ | publisher=Cancer Research UK |title=Professor Malcolm Stevens – The Story of Temozolomide}} Video
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Category:People educated at Bolton School
Category:Alumni of the University of Nottingham
Category:Academics of the University of Nottingham
Category:Academics of Aston University