Mammalian CPEB3 ribozyme

{{Short description|Ribozyme}}{{Infobox rfam

| Name = Mammalian CPEB3 ribozyme

| image = RF00622.jpg

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| caption = Predicted secondary structure and sequence conservation of CPEB3_ribozyme

| Symbol = CPEB3_ribozyme

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| Rfam = RF00622

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| RNA_type = Gene; ribozyme

| Tax_domain = Eukaryota

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| SO = {{SO|0000374}}

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The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation.{{cite journal |vauthors = Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW |title= A genomewide search for ribozymes reveals an HDV-like sequence in thehuman CPEB3 gene. |journal= Science |volume= 313 |issue= 5794|pages= 1788–1792 |year= 2006 |pmid=16990549 |doi= 10.1126/science.1129308|bibcode= 2006Sci...313.1788S |s2cid= 43309772 }} This ribozyme is highly conserved and

found only in mammals. The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus ribozyme.{{cite journal |vauthors=Chadalavada DM, Gratton EA, Bevilacqua PC |title=The Human HDV-like CPEB3 Ribozyme Is Intrinsically Fast-Reacting. |journal=Biochemistry |volume= 49|issue= 25|pages= 5321–5330|year=2010 |pmid=20524672 |pmc=2890282 |doi=10.1021/bi100434c}} Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.{{cite journal|last=Webb|first=CH |author2=Riccitelli, NJ |author3=Ruminski, DJ |author4=Lupták, A|title=Widespread occurrence of self-cleaving ribozymes.|journal=Science|date=Nov 13, 2009|volume=326|issue=5955|pages=953|pmid=19965505|doi=10.1126/science.1178084|pmc=3159031|bibcode=2009Sci...326..953W }}