Mannan-binding lectin-associated serine protease-2

{{Infobox enzyme

| Name = Mannan-binding lectin-associated serine protease-2

| EC_number = 3.4.21.104

| CAS_number = 214915-16-9

| GO_code =

| image =

| width =

| caption =

}}

Mannan-binding lectin-associated serine protease-2 ({{EC number|3.4.21.104}}, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme.{{cite journal | vauthors = Matsushita M, Fujita T | title = Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease | journal = The Journal of Experimental Medicine | volume = 176 | issue = 6 | pages = 1497–502 | date = December 1992 | pmid = 1460414 | pmc = 2119445 | doi = 10.1084/jem.176.6.1497 }}{{cite journal | vauthors = Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC | title = A second serine protease associated with mannan-binding lectin that activates complement | journal = Nature | volume = 386 | issue = 6624 | pages = 506–10 | date = April 1997 | pmid = 9087411 | doi = 10.1038/386506a0 }}{{cite journal | vauthors = Rossi V, Cseh S, Bally I, Thielens NM, Jensenius JC, Arlaud GJ | title = Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40880–7 | date = November 2001 | pmid = 11527969 | doi = 10.1074/jbc.M105934200 | doi-access = free }}{{cite journal | vauthors = Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Závodszky P | title = Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments | journal = Journal of Immunology | volume = 170 | issue = 3 | pages = 1374–82 | date = February 2003 | pmid = 12538697 | doi = 10.4049/jimmunol.170.3.1374 | doi-access = free }}{{cite journal | vauthors = Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G, Závodszky P | title = The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions | journal = Journal of Molecular Biology | volume = 342 | issue = 5 | pages = 1533–46 | date = October 2004 | pmid = 15364579 | doi = 10.1016/j.jmb.2004.07.014 }}{{cite journal | vauthors = Chen CB, Wallis R | title = Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases | journal = The Journal of Biological Chemistry | volume = 279 | issue = 25 | pages = 26058–65 | date = June 2004 | pmid = 15060079 | doi = 10.1074/jbc.M401318200 | doi-access = free }}{{cite journal | vauthors = Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ, Thielens NM | title = The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases | journal = Journal of Immunology | volume = 174 | issue = 5 | pages = 2870–7 | date = March 2005 | pmid = 15728497 | doi = 10.4049/jimmunol.174.5.2870 | doi-access = free }} This enzyme catalyses the following chemical reaction

: Selective cleavage after Arg²²³ in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg⁷⁶ in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)

This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.