Manuel Alves Grande River

{{Infobox river

| name = Manuel Alves Grande River

| image = Bacia_do_rio_Manuel_Alves_Grande.jpg

| image_size =

| image_caption = Area bathed by the Manuel Alves Grande river basin

| source1_location = Tocantins and Maranhão states

| mouth = Tocantins River

| mouth_location =

| subdivision_type1 = Country

| subdivision_name1 = Brazil

| length = 234,87 km{{cite web|title=Rio Manuel Alves Grande |url=https://www.researchgate.net/publication/325078532_Dinamica_hidrossedimentologica_de_duas_sub-bacias_hidrograficas_localizadas_no_Estado_do_Tocantins/fulltext/5af5ba900f7e9b026bcec219/325078532_Dinamica_hidrossedimentologica_de_duas_sub-bacias_hidrograficas_localizadas_no_Estado_do_Tocantins.pdf?origin=publication_detail}}

| source1_elevation =

| mouth_elevation =

| discharge1_avg =

| basin_size =

}}

The Manuel Alves Grande River is a river of Tocantins and Maranhão states, dividing the north and northeast regions of Brazil. It is a tributary of the Tocantins River.