Manuel II

Manuel II may refer to:

• Manuel II of Trebizond (c. 1324–1333), Emperor of Trebizond
• Manuel II Palaiologos (1350–1425), Byzantine Emperor
• Patriarch Manuel II of Constantinople, Patriarch of Constantinople from 1244 to 1255
• Manuel II of Portugal (1889–1932), King of Portugal
• Manuel II, Patriarch of Lisbon (1888–1977)

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