Marginal nucleus of spinal cord

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| Name = Marginal nucleus of spinal cord

| Latin = nucleus marginalis medullae spinalis, lamina spinalis I

| Image = Medulla spinalis - Substantia grisea - English.svg

| Caption = Medulla spinalis (Rexed lamina I labeled at upper left.)

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The marginal nucleus of spinal cord, posteromarginal nucleus, or spinal lamina 1 (Rexed lamina 1) is located at the most dorsal aspect of the posterior grey column of the spinal cord. The neurons located here receive input primarily from Lissauer's tract and relay information related to pain and temperature sensation.{{Cite journal |last=Dafny |first=Nachum |date=2020-10-07 |title=Anatomy of the Spinal Cord |url=https://nba.uth.tmc.edu/neuroscience/s2/chapter03.html |journal=Department of Neurobiology and Anatomy |volume=3 |issue=2 |via=University of Texas Health Science Center at Houston}}{{Cite journal |last1=Almarestani |first1=L. |last2=Waters |first2=S. M. |last3=Krause |first3=J. E. |last4=Bennett |first4=G. J. |last5=Ribeiro-da-Silva |first5=A. |date=2007-09-20 |title=Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the rat |url=https://pubmed.ncbi.nlm.nih.gov/17640051/ |journal=The Journal of Comparative Neurology |volume=504 |issue=3 |pages=287–297 |doi=10.1002/cne.21410 |issn=0021-9967 |pmid=17640051|s2cid=35818839 }} Pain sensation relayed here cannot be modulated, e.g. pain from burning the skin.

The axons of neurons contribute to the lateral spinothalamic tract.{{Citation |last1=Ganapathy |first1=Muthu Kuzhali |title=Neuroanatomy, Spinal Cord Morphology |date=2022 |url=http://www.ncbi.nlm.nih.gov/books/NBK545206/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31424790 |access-date=2023-01-20 |last2=Reddy |first2=Vamsi |last3=Tadi |first3=Prasanna}}{{Citation |last1=Sheikh |first1=Nafiz K. |title=Neuroanatomy, Substantia Gelatinosa |date=2022 |url=http://www.ncbi.nlm.nih.gov/books/NBK551522/ |work=StatPearls |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31855366 |access-date=2023-01-20 |last2=Dua |first2=Anterpreet}}