Matrix metalloproteinase inhibitor
{{refimprove|date=December 2013}}
A matrix metalloproteinase inhibitor (INN stem {{not a typo|–mastat}}{{cite web|title=The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances|url=https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf|publisher=World Health Organization|access-date=5 November 2016}}) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs.{{cite journal |last1=Coussens |first1=L. M. |author-link=Lisa Coussens |year=2002 |title=Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations |journal=Science |volume=295 |issue=5564 |pages=2387–2392 |bibcode=2002Sci...295.2387C |doi=10.1126/science.1067100 |issn=0036-8075 |pmid=11923519 |s2cid=19944201}} Examples include:
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria.{{cite journal|journal=Biochemistry Research International |title=Metalloproteinase Inhibitors Stts and Scope from Marine Organisms|year=2010|author1=Noel Vinay Thomas |author2=Se Kwon Kim |pmc=3004377|pmid=21197102|doi=10.1155/2010/845975|volume=2010|pages=845975|doi-access=free}}