Matthew Hurles
{{Use British English|date=May 2024}}
{{Use dmy dates|date=May 2024}}
{{Infobox scientist
| name = Matt Hurles
| birth_name = Matthew Edward Hurles
| birth_place = Hammersmith, London, England
| honorific_suffix = {{post-nominals|country=GBR|FRS|FMedSci|size=100%}}
| birth_date = {{birth date and age|1974|05|08|df=y}}
| workplaces = Wellcome Sanger Institute
University of Cambridge
Congenica Ltd{{cite web|archiveurl=https://web.archive.org/web/20191025085448/https://beta.companieshouse.gov.uk/officers/rTX3CoOyFrCnm5mx-EJOVLkkAuM/appointments|archivedate=2019-10-25|url=https://beta.companieshouse.gov.uk/officers/rTX3CoOyFrCnm5mx-EJOVLkkAuM/appointments|publisher=Companies House|website=companieshouse.gov.uk|location=London|author=Anon|year=2018|title=Matthew Hurles: Congenica Ltd}}
| fields = Genetics
| education = Hampton School
| alma_mater =University of Oxford (BA)
University of Leicester (PhD)
| thesis_title =Mutation and variability of the human Y chromosome
| thesis_url =https://hdl.handle.net/2381/30320
| thesis_year =1999
| doctoral_advisor = Mark Jobling
| awards = Crick Lecture (2013)
| website = {{URL|https://www.sanger.ac.uk/people/directory/hurles-matthew}}}}
Matthew Edward Hurles (born 1974){{Who's Who | author= Anon | year= 2023 | title = HURLES, Dr. Matthew | id= U290131 | doi= 10.1093/ww/9780199540884.013.U290131|edition = online Oxford University Press|location=Oxford }} is a British scientist who is director of the Wellcome Sanger Institute{{Scopus id}}{{Google scholar id}} and an honorary professor of Human Genetics and Genomics at the University of Cambridge.{{EuropePMC}}
Education
Hurles was privately educated at Hampton School and the University of Oxford where he was awarded a Bachelor of Arts degree in Biochemistry. He completed his PhD in 1999 on the genetics of the Y chromosome at the University of Leicester supervised by Mark Jobling{{cite thesis|degree=PhD|publisher=University of Leicester|title=Mutation and variability of the human Y chromosome|first= Matthew|last=Hurles|url=https://lra.le.ac.uk/handle/2381/30320|year=1999|id={{EThOS|uk.bl.ethos.696631}}|website=le.ac.uk|oclc=505103676|hdl=2381/30320}} {{open access}}{{cite journal|last1=Hurles|first1=Matthew E.|last2=Veitia|first2=Reiner|last3=Arroyo|first3=Eduardo|last4=Armenteros|first4=Manuel|last5=Bertranpetit|first5=Jaume|last6=Pérez-Lezaun|first6=Anna|last7=Bosch|first7=Elena|last8=Shlumukova|first8=Maria|last9=Cambon-Thomsen|first9=Anne|last10=McElreavey|first10=Ken|last11=López de Munain|first11=Adolfo|last12=Röhl|first12=Arne|last13=Wilson|first13=Ian J.|last14=Singh|first14=Lalji|last15=Pandya|first15=Arpita|last16=Santos|first16=Fabrício R.|last17=Tyler-Smith|first17=Chris|last18=Jobling|first18=Mark A.|title=Recent Male-Mediated Gene Flow over a Linguistic Barrier in Iberia, Suggested by Analysis of a Y-Chromosomal DNA Polymorphism|journal=The American Journal of Human Genetics|volume=65|issue=5|year=1999|pages=1437–1448|issn=0002-9297|doi=10.1086/302617|pmid=10521311 |pmc=1288297 }}{{cite journal|last1=Hurles|first1=Matthew E.|last2=Irven|first2=Catherine|last3=Nicholson|first3=Jayne|last4=Taylor|first4=Paul G.|last5=Santos|first5=Fabricio R.|last6=Loughlin|first6=John|last7=Jobling|first7=Mark A.|last8=Sykes|first8=Bryan C.|title=European Y-Chromosomal Lineages in Polynesians: A Contrast to the Population Structure Revealed by mtDNA|journal=The American Journal of Human Genetics|volume=63|issue=6|year=1998|pages=1793–1806|issn=0002-9297|doi=10.1086/302147|pmid=9837833 |pmc=1377652 }}
Research and career
Hurles research investigates the causes and consequences of new mutations as DNA is passed from one generation to the next. He is best known for his work on characterizing the extent and impact of structural variation in the human genome and on deciphering the genetic architecture of severe neurodevelopmental disorders.
Hurles group has used large-scale genomic studies to highlight the predominant role that new mutations of many different types play in causing diverse developmental disorders and has led to the discovery of tens of previously unrecognised genetic diseases.{{cite journal|title=A map of human genome variation from population-scale sequencing|journal=Nature|volume=467|issue=7319|year=2010|pages=1061–1073|issn=0028-0836|doi=10.1038/nature09534|pmid= 20981092 |pmc=3042601 |author=The 1000 Genomes Project Consortium|bibcode=2010Natur.467.1061T }}{{cite journal|title=An integrated map of genetic variation from 1,092 human genomes|journal=Nature|volume=491|issue=7422|year=2012|pages=56–65|issn=0028-0836|doi=10.1038/nature11632|author=The 1000 Genomes Project Consortium|pmid=23128226 |pmc=3498066 |bibcode=2012Natur.491...56T }}{{cite journal|last1=Redon|first1=Richard|last2=Ishikawa|first2=Shumpei|last3=Fitch|first3=Karen R.|last4=Feuk|first4=Lars|last5=Perry|first5=George H.|last6=Andrews|first6=T. Daniel|last7=Fiegler|first7=Heike|last8=Shapero|first8=Michael H.|last9=Carson|first9=Andrew R.|last10=Chen|first10=Wenwei|last11=Cho|first11=Eun Kyung|last12=Dallaire|first12=Stephanie|last13=Freeman|first13=Jennifer L.|last14=González|first14=Juan R.|last15=Gratacòs|first15=Mònica|last16=Huang|first16=Jing|last17=Kalaitzopoulos|first17=Dimitrios|last18=Komura|first18=Daisuke|last19=MacDonald|first19=Jeffrey R.|last20=Marshall|first20=Christian R.|last21=Mei|first21=Rui|last22=Montgomery|first22=Lyndal|last23=Nishimura|first23=Kunihiro|last24=Okamura|first24=Kohji|last25=Shen|first25=Fan|last26=Somerville|first26=Martin J.|last27=Tchinda|first27=Joelle|last28=Valsesia|first28=Armand|last29=Woodwark|first29=Cara|last30=Yang|first30=Fengtang|last31=Zhang|first31=Junjun|last32=Zerjal|first32=Tatiana|last33=Zhang|first33=Jane|last34=Armengol|first34=Lluis|last35=Conrad|first35=Donald F.|last36=Estivill|first36=Xavier|last37=Tyler-Smith|first37=Chris|last38=Carter|first38=Nigel P.|last39=Aburatani|first39=Hiroyuki|last40=Lee|first40=Charles|last41=Jones|first41=Keith W.|last42=Scherer|first42=Stephen W.|last43=Hurles|first43=Matthew E.|title=Global variation in copy number in the human genome|journal=Nature|volume=444|issue=7118|year=2006|pages=444–454|issn=0028-0836|doi=10.1038/nature05329|pmid=17122850 |pmc=2669898 |bibcode=2006Natur.444..444R }}
=Awards and honours=
Hurles was elected a Fellow of the Royal Society (FRS) in 2019.{{cite web|archiveurl=https://web.archive.org/web/20190424061447/https://royalsociety.org/people/matthew-hurles-14100/|archivedate=2019-04-24|url=https://royalsociety.org/people/matthew-hurles-14100/|website=royalsociety.org|publisher=Royal Society|location=London|author=Anon|year=2019|title=Professor Matthew Hurles FMedSci FRS}} One or more of the preceding sentences incorporates text from the royalsociety.org website where: {{blockquote|“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --{{Webarchive|url=https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/|title=Royal Society Terms, conditions and policies|date=2016-11-11}}}} He is also a Fellow of the Academy of Medical Sciences (FMedSci) and was awarded the Crick Medal and Lecture in 2013.
References
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Category:Fellows of the Royal Society
Category:People educated at Hampton School
Category:Fellows of the Academy of Medical Sciences (United Kingdom)