Mdx mouse

{{Short description|Popular model for studying Duchenne muscular dystrophy}}

{{lowercase title}}

The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD).{{cite thesis|degree=PhD|publisher=University of Liverpool|title=Mechanisms skeletal muscle damage in the dystrophin-deficient MDX mouse|first= Anne.|last=McArdle|author-link=Anne McArdle|date=1993|id={{EThOS|uk.bl.ethos.385144}}|oclc=53496566}}{{Cite journal |pmc = 344791|year = 1984|last1 = Bulfield|first1 = G.|title = X chromosome-linked muscular dystrophy (mdx) in the mouse|journal = Proceedings of the National Academy of Sciences of the United States of America|volume = 81|issue = 4|pages = 1189–1192|last2 = Siller|first2 = W. G.|last3 = Wight|first3 = P. A.|last4 = Moore|first4 = K. J.|pmid = 6583703|bibcode = 1984PNAS...81.1189B|doi = 10.1073/pnas.81.4.1189|doi-access = free}} The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a glutamine to STOP codon. This causes the muscle cells to produce a small, nonfunctional dystrophin protein.{{Cite web|url=http://www.parentprojectmd.org/site/PageServer?pagename=Advance_research_strategies_animalmodels|title=Animal Models - Parent Project Muscular Dystrophy|website=parentprojectmd.org|access-date=2016-05-03}} As a result, the mouse has a mild form of DMD where there is increased muscle damage and weakness.