Medio Creek

{{Infobox river

| name = Medio Creek

| image = File:RecordedTexasHistoricLandmark_MedioCreek.jpg

| image_size =

| image_caption = Texas Historic Landmark marker for Medio Creek, beside a dry riverbed, US 59 about 4 miles NE of Beeville

| source1_location = Texas

| mouth_location =

| subdivision_type1 = Country

| subdivision_name1 = United States

| length =

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}}

Medio Creek is a river in Texas, that is a tributary of the Mission River.