Mestranol/norethisterone

{{Short description|Combined oral contraceptive medication}}

{{Distinguish|Mestranol/noretynodrel}}

{{Drugbox

| type = combo

| drug_name =

| component1 = Mestranol

| class1 = Estrogen

| component2 = Norethisterone

| class2 = Progestogen

| tradename = Norethin, Noriday, Norinyl, Norquen, Ortho-Novum, others

| Drugs.com = {{drugs.com|monograph|estrogen-progestin-combinations}}

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| routes_of_administration = By mouth

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| ATC_prefix = None

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| legal_US = Rx-only

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| CAS_number = 8015-29-0

| PubChem = 63022

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Mestranol/norethisterone (brand names Norethin, Noriday, Norinyl, Norquen, Ortho-Novum, others) is a combination of the estrogen Mestranol and the progestin norethisterone (norethindrone) which was introduced in 1963 and was the second combined oral contraceptive to be marketed, following mestranol/noretynodrel in 1960.{{cite book| vauthors = Marks L |title=Sexual Chemistry: A History of the Contraceptive Pill|url=https://books.google.com/books?id=_i-s4biQs7MC&pg=PA74|year=2010|publisher=Yale University Press|isbn=978-0-300-16791-7|pages=74, 76}} Although most mestranol-containing oral contraceptive formulations have been discontinued, the combination remains available today in the United States in a single formulation under the brand name Norinyl 1+50 28-Day.{{cite web | title = Drugs@FDA: FDA Approved Drug Products | publisher = United States Food and Drug Administration | accessdate = 22 December 2016 | url = http://www.accessdata.fda.gov/scripts/cder/daf/}} It has largely been superseded by ethinylestradiol/norethisterone, which has been marketed under many of the same brand names.{{cite book| vauthors = Blum RW |title=Adolescent Health Care: Clinical Issues|url=https://books.google.com/books?id=36PpAgAAQBAJ&pg=PA216|date=22 October 2013|publisher=Elsevier Science|isbn=978-1-4832-7738-7|pages=216–}}{{cite book| vauthors = Varney H, Kriebs JM, Gegor CL |title=Varney's Midwifery|url=https://archive.org/details/varneysmidwifery0000varn|url-access=registration|year=2004|publisher=Jones & Bartlett Learning|isbn=978-0-7637-1856-5|pages=[https://archive.org/details/varneysmidwifery0000varn/page/515 515]–}}