Metalloestrogen

{{short description|Class of chemical compounds}}

Metalloestrogens are a class of inorganic xenoestrogens which can affect the gene expression of human cells responding to estrogen. Effects are related to the physiologic function of estrogen because metalloestrogens have shown affinity for estrogen receptors. Because they can mimic estrogen thus activating the receptor, they are considered harmful and potentially linked with breast cancer.{{cite journal|last=Darbre|first=P. D.|title=Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast|journal=Journal of Applied Toxicology|year=2006|volume=26|issue=3|pages=191–197|doi=10.1002/jat.1135|pmid=16489580|s2cid=26291680 }}

List of metalloestrogens include aluminium, antimony, arsenite, barium, cadmium,{{cite book

|last1=Thévenod

|first1=Frank

|last2=Lee

|first2=Wing-Kee

|editor=Astrid Sigel, Helmut Sigel and Roland K. O. Sigel

|title=Cadmium: From Toxicology to Essentiality

|series=Metal Ions in Life Sciences

|volume=11

|year=2013

|publisher=Springer

|pages=465–466

|chapter=Chapter 14. Toxicology of cadmium and its damage to mammalian organs

|doi=10.1007/978-94-007-5179-8_14|pmid=23430781

}} chromium (Cr(II)), cobalt, copper, lead, mercury, nickel, selenite, tin and vanadate.{{Cite journal |last=Byrne |first=Celia |last2=Divekar |first2=Shailaja D |last3=Storchan |first3=Geoffrey B |last4=Parodi |first4=Daniela A |last5=Martin |first5=Mary Beth |date=2013-01-22 |title=Metals and Breast Cancer |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC4017651/ |journal=Journal of mammary gland biology and neoplasia |language=en |volume=18 |issue=1 |doi=10.1007/s10911-013-9273-9 |archive-url=http://web.archive.org/web/20250104023250/https://pmc.ncbi.nlm.nih.gov/articles/PMC4017651/ |archive-date=2025-01-04|pmc=4017651 }}