Metallopharmaceutical

{{Short description|Drug that contains a metal as an active ingredient}}

File:Carboplatin-2D-skeletal.png, an example of a metallopharmaceutical]]

A metallopharmaceutical is a drug that contains a metal as an active ingredient.{{cite book |vauthors=Guo J, Sadler PJ | title = Medicinal Inorganic Chemistry | journal = Adv. Inorg. Chem. | year = 1999 | volume = 49 | pages = 183–306 | doi = 10.1016/S0898-8838(08)60271-8 | series = Advances in Inorganic Chemistry | isbn = 9780120236497}}{{cite journal |vauthors=Ray S, Mohan R, Singh JK, Samantaray MK, Shaikh MM, Panda D, Ghosh P | title = Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes | journal = J. Am. Chem. Soc. | volume = 129 | issue = 48 | pages = 15042–53 |date=December 2007 | pmid = 17988129 | doi = 10.1021/ja075889z | bibcode = 2007JAChS.12915042R }} Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals is crucially dependent on the respective trace metal binding forms.{{cite book

|year=1999

|volume=20

|pages=71–103

|vauthors=Günther K, Weber G |title=Analytiker-Taschenbuch

|chapter=Elementspeziesanalytik: Ein Überblick

|doi=10.1007/978-3-642-59914-9_3

|isbn=978-3-642-64181-7

}}

Examples of metallopharmaceuticals include:

• bismuth subsalicylate – a mild anti-diarrheal also used in treating peptic ulcers caused by antibiotic-resistant H. pylori{{cite journal|vauthors=Fischbach L, Evans EL |title = Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori|journal = Aliment. Pharmacol. Ther.|volume = 26|issue = 3|pages = 343–57|date=August 2007|pmid = 17635369|doi = 10.1111/j.1365-2036.2007.03386.x| s2cid=20973127 |doi-access = }}{{cite journal|vauthors=Graham DY, Shiotani A |title = New concepts of resistance in the treatment of Helicobacter pylori infections|journal = Nat. Clin. Pract. Gastroenterol. Hepatol.|volume = 5|issue = 6|pages = 321–31|date=June 2008|pmid = 18446147|doi = 10.1038/ncpgasthep1138|pmc = 2841357}}
• cisplatin and carboplatin – platinum containing anticancer agents{{cite journal |vauthors=Lokich J, Anderson N | title = Carboplatin versus cisplatin in solid tumors: an analysis of the literature | journal = Ann. Oncol. | volume = 9 | issue = 1 | pages = 13–21 |date=January 1998 | pmid = 9541678 | doi = 10.1023/A:1008215213739| doi-access = free }}{{cite journal |vauthors=Go RS, Adjei AA | title = Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin | journal = J. Clin. Oncol. | volume = 17 | issue = 1 | pages = 409–22 |date=January 1999 | pmid = 10458260 | doi = 10.1200/JCO.1999.17.1.409}}
• gold salts such as auranofin – anti-inflammatory for treatment of arthritis{{cite journal |vauthors=Messori L, Marcon G | title = Gold complexes in the treatment of rheumatoid arthritis | journal = Met. Ions Biol. Syst. | volume = 41 | pages = 279–304 | year = 2004 | pmid = 15206120 }}{{cite journal |vauthors=Gaujoux-Viala C, Smolen JS, Landewé R, Dougados M, Kvien TK, Mola EM, Scholte-Voshaar M, van Riel P, Gossec L | title = Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis | journal = Ann. Rheum. Dis. | volume = 69 | issue = 6 | pages = 1004–9 |date=June 2010 | pmid = 20447954 | doi = 10.1136/ard.2009.127225 | s2cid = 30886393 }}
• silver sulfadiazine – antibacterial{{cite journal | author = Fuller FW | title = The side effects of silver sulfadiazine | journal = J. Burn Care Res. | volume = 30 | issue = 3 | pages = 464–70 | year = 2009 | pmid = 19349889 | doi = 10.1097/BCR.0b013e3181a28c9b | s2cid = 3676574 }}{{cite journal |vauthors=Carter MJ, Tingley-Kelley K, Warriner RA | title = Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta-analysis | journal =J. Am. Acad. Dermatol. | volume = 63 | issue = 4 | pages = 668–79 |date=October 2010 | pmid = 20471135 | doi = 10.1016/j.jaad.2009.09.007 }}
• zinc pyrithione – antibacterial and antifungal{{cite journal |vauthors=Guthery E, Seal LA, Anderson EL | title = Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects | journal = Am J Infect Control | volume = 33 | issue = 1 | pages = 15–22 |date=February 2005 | pmid = 15685130 | doi = 10.1016/j.ajic.2004.07.012 | pmc = 7119132 }}